【结 构 式】 |
【分子编号】56743 【品名】methyl 3-{1-(2-fluorophenyl)-3-[(3-isoquinolinylcarbonyl)amino]-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl}propanoate 【CA登记号】 |
【 分 子 式 】C29H24FN3O5 【 分 子 量 】513.5251832 【元素组成】C 67.83% H 4.71% F 3.7% N 8.18% O 15.58% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)The condensation of 3-amino-1-(2-fluorophenyl)-6-methoxyindolin-2-one (I) with isoquinolin-3-ylcarbonyl chloride (II) by means of NaHCO3 in chloroform/dichloromethane/water gives the corresponding amide (III), which is condensed with methyl acrylate (IV) by means of K2CO3 in acetone to yield the propionic ester derivative (V). Finally, the ester group of (V) is hydrolyzed with NaOH in ethanol to afford the target propionic acid derivative as a racemic compound.
【1】 Yamada, K.; Hikota, M.; Shikano, T.; Nagasaki, M. (Tanabe Seiyaku Co., Ltd.); 2-Oxoindoline deriv.. EP 0731091; US 5807883; WO 9514668 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 52869 | 3-amino-1-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one | C15H13FN2O2 | 详情 | 详情 | |
(II) | 56739 | 3-isoquinolinecarboxylic acid | 203626-75-9 | C10H7NO2 | 详情 | 详情 |
(III) | 56742 | N-[1-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]-3-isoquinolinecarboxamide | C25H18FN3O3 | 详情 | 详情 | |
(IV) | 14156 | methyl acrylate | 96-33-3 | C4H6O2 | 详情 | 详情 |
(V) | 56743 | methyl 3-{1-(2-fluorophenyl)-3-[(3-isoquinolinylcarbonyl)amino]-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl}propanoate | C29H24FN3O5 | 详情 | 详情 |
Extended Information