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【结 构 式】

【分子编号】52643

【品名】tricyclo[3.3.1.1~3,7~]dec-1-yl 4-nitrobenzoate

【CA登记号】

【 分 子 式 】C17H19NO4

【 分 子 量 】301.3422

【元素组成】C 67.76% H 6.36% N 4.65% O 21.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

1-Adamantanol (I) was esterified with 4-nitrobenzoyl chloride (II) in the presence of pyridine, yielding adamantanyl 4-nitrobenzoate (III). After catalytic hydrogenation of the nitro group of (III), the resultant aniline (IV) was condensed with 2,5-dihydroxybenzaldehyde (V) to afford the corresponding Schiff base (VI). Subsequent hydrogenation of the imine double bond of (VI) over Pd/C gave rise to the target amine.

1 Narayanan, V.L.; Sausville, E.A.; Kaur, G.; Varma, R.K. (US Department of Health & Human Services); Disubstd. lavendustin A analogs and pharmaceutical compsns. comprising the analogs. EP 1060160; WO 9943636 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 52642 1-Adamantanol; 1-Hydroxyadamantane; Tricyclo[3.3.1.1]decan-1-ol 768-95-6 C10H16O 详情 详情
(II) 18941 p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride 122-04-3 C7H4ClNO3 详情 详情
(III) 52643 tricyclo[3.3.1.1~3,7~]dec-1-yl 4-nitrobenzoate C17H19NO4 详情 详情
(IV) 52644 tricyclo[3.3.1.1~3,7~]dec-1-yl 4-aminobenzoate C17H21NO2 详情 详情
(V) 52645 5-Hydroxysalicylaldehyde; Gentisinaldehyde; 2,5-Dihydroxybenzaldehyde 1194-98-5 C7H6O3 详情 详情
(VI) 52646 tricyclo[3.3.1.1~3,7~]dec-1-yl 4-{[(2,5-dihydroxyphenyl)methylidene]amino}benzoate C24H25NO4 详情 详情
Extended Information