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【结 构 式】 
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【分子编号】52351 【品名】3-(bromomethyl)-1,1'-biphenyl 【CA登记号】 |
【 分 子 式 】C13H11Br 【 分 子 量 】247.13434 【元素组成】C 63.18% H 4.49% Br 32.33% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)The known tetrasulfonamide (I) was alkylated with m-phenylbenzyl bromide (II) in the presence of NaH to afford the dialkylated derivative (III). The mesitylenesulfonyl protecting groups of (III) were then removed by treatment with HBr in HOAc to furnish the title tetramine.
| 【1】 Zou, Y.; Wu, Z.; Sirisoma, N.; et al.; Novel alkylpolyamide analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett 2001, 11, 12, 1613. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55090 | N-(3-{(mesitylsulfonyl)[7-((mesitylsulfonyl){3-[(mesitylsulfonyl)amino]propyl}amino)heptyl]amino}propyl)-2,4,6-trimethylbenzenesulfonamide | C49H72N4O8S4 | 详情 | 详情 | |
| (II) | 52351 | 3-(bromomethyl)-1,1'-biphenyl | C13H11Br | 详情 | 详情 | |
| (III) | 55091 | N-{3-[([1,1'-biphenyl]-3-ylmethyl)(mesitylsulfonyl)amino]propyl}-N-{7-[{3-[([1,1'-biphenyl]-3-ylmethyl)(mesitylsulfonyl)amino]propyl}(mesitylsulfonyl)amino]heptyl}-2,4,6-trimethylbenzenesulfonamide | C75H92N4O8S4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)The title compound was prepared by alkylation of 7-piperazinylbenzoxazol-2(3H)-one (I) with 3-phenylbenzyl bromide (II) in the presence of diisopropyl ethyl amine and KI in refluxing acetonitrile.
| 【1】 Feenstra, R.W.; et al.; New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-receptor and serotonin 5-HT1A-receptor affinities. Bioorg Med Chem Lett 2001, 11, 17, 2345. |
| 【2】 Feenstra, R.W.; Kruse, C.G.; Tulp, M.T.M.; Kuipers, W.; Long, S.K. (Duphar International Research BV); Piperazine and piperidine cpds.. JP 2000507949; US 6225312; WO 9736893 . |
Extended Information