|
【结 构 式】 
|
【药物名称】 【化学名称】N,N'-Bis[3-(biphenyl-3-ylmethylamino)propyl]heptane-1,7-diamine 【CA登记号】 【 分 子 式 】C39H52N4 【 分 子 量 】576.87609 |
【开发单位】Albert Einstein College of Medicine (Originator), Johns Hopkins University (Originator), Pace University (Originator), Wayne State University (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Treatment of Protozoal Diseases |
合成路线1
The known tetrasulfonamide (I) was alkylated with m-phenylbenzyl bromide (II) in the presence of NaH to afford the dialkylated derivative (III). The mesitylenesulfonyl protecting groups of (III) were then removed by treatment with HBr in HOAc to furnish the title tetramine.
| 【1】 Zou, Y.; Wu, Z.; Sirisoma, N.; et al.; Novel alkylpolyamide analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett 2001, 11, 12, 1613. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55090 | N-(3-{(mesitylsulfonyl)[7-((mesitylsulfonyl){3-[(mesitylsulfonyl)amino]propyl}amino)heptyl]amino}propyl)-2,4,6-trimethylbenzenesulfonamide | C49H72N4O8S4 | 详情 | 详情 | |
| (II) | 52351 | 3-(bromomethyl)-1,1'-biphenyl | C13H11Br | 详情 | 详情 | |
| (III) | 55091 | N-{3-[([1,1'-biphenyl]-3-ylmethyl)(mesitylsulfonyl)amino]propyl}-N-{7-[{3-[([1,1'-biphenyl]-3-ylmethyl)(mesitylsulfonyl)amino]propyl}(mesitylsulfonyl)amino]heptyl}-2,4,6-trimethylbenzenesulfonamide | C75H92N4O8S4 | 详情 | 详情 |
Extended Information