2-{2-[5-chloro-1-benzofuran-3(2H)-ylidene]hydrazino}benzoic acid -Drug Synthesis Database

【结构式】

【分子编号】52307

【品名】2-{2-[5-chloro-1-benzofuran-3(2H)-ylidene]hydrazino}benzoic acid

【CA登记号】

【分子式】C₁₅H₁₁ClN₂O₃

【分子量】302.71672

【元素组成】C 59.52% H 3.66% Cl 11.71% N 9.25% O 15.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation between 5-chloro-3(2H)benzofuranone (I) and 2-hydrazinobenzoic acid (II) afforded the corresponding hydrazone (III). This was subjected to microwave-promoted Fischer indole cyclization in formic acid to produce the target benzofuroindole tetracyclic system.

参考文献中间体

合成目标

【1】 Butera, J.A.; et al.; Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole- and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids. Bioorg Med Chem Lett 2001, 11, 16, 2093.
【2】 Butera, J.A.; Antane, S.A.; Lennox, J.R. (Wyeth); Substd. benzofuranoindoles and indenoindoles as novel potassium channel openers. EP 1135393; US 6288099; WO 0034285 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	52306	5-Chloro-3(2H)-Benzofuranone		C₈H₅ClO₂	详情	详情
(II)	47957	2-hydrazinobenzoic acid	52356-01-1	C₇H₈N₂O₂	详情	详情
(III)	52307	2-{2-[5-chloro-1-benzofuran-3(2H)-ylidene]hydrazino}benzoic acid		C₁₅H₁₁ClN₂O₃	详情	详情

Extended Information