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【结 构 式】 
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【药物名称】 【化学名称】8-Chloro-10H-[1]benzofuro[3,2-b]indole-1-carboxylic acid 【CA登记号】275377-99-6 【 分 子 式 】C15H8ClNO3 【 分 子 量 】285.68891 |
【开发单位】Wyeth Pharmaceuticals (Originator) 【药理作用】RENAL-UROLOGIC DRUGS, Urinary Incontinence Therapy, Large Conductance BK(Ca) Channel Activators |
合成路线1
The condensation between 5-chloro-3(2H)benzofuranone (I) and 2-hydrazinobenzoic acid (II) afforded the corresponding hydrazone (III). This was subjected to microwave-promoted Fischer indole cyclization in formic acid to produce the target benzofuroindole tetracyclic system.
| 【1】 Butera, J.A.; et al.; Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole- and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids. Bioorg Med Chem Lett 2001, 11, 16, 2093. |
| 【2】 Butera, J.A.; Antane, S.A.; Lennox, J.R. (Wyeth); Substd. benzofuranoindoles and indenoindoles as novel potassium channel openers. EP 1135393; US 6288099; WO 0034285 . |
Extended Information