isochromeno[6',5',4':10,5,6]anthra[2,1,9-def]isochromene-1,3,8,10-tetrone -Drug Synthesis Database

【结构式】

【分子编号】52086

【品名】isochromeno[6',5',4':10,5,6]anthra[2,1,9-def]isochromene-1,3,8,10-tetrone

【CA登记号】

【分子式】C₂₄H₈O₆

【分子量】392.32392

【元素组成】C 73.48% H 2.06% O 24.47%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title bis-imide was synthesized by condensation of 3,4,9,10-perylenetetracarboxylic acid dianhydride (I) with N-(3-aminopropyl)morpholine (II) in hot n-butanol.

参考文献中间体

合成目标

【1】 Kerwin, S.M.; et al.; G-quadruplex DNA binding selectivity of perylenetetracarboxylic acid diimides is PH dependent and mediated by ligand aggregation. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 142.
【2】 Salazar, M.; Kerwin, S.M.; Hurley, L.H.; Fedoroff, O.Y. (University of Texas System); Inhibition of human telomerase by a G-quadruplex-interaction cpd.. US 6156763; WO 9940087 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	52086	isochromeno[6',5',4':10,5,6]anthra[2,1,9-def]isochromene-1,3,8,10-tetrone		C₂₄H₈O₆	详情	详情
(II)	25440	3-(4-morpholinyl)-1-propanamine	123-00-2	C₇H₁₆N₂O	详情	详情

Extended Information