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【结 构 式】 
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【药物名称】Tel-01 【化学名称】2,9-Bis[3-(4-morpholinyl)propyl]anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone 【CA登记号】154355-15-4 【 分 子 式 】C38H36N4O6 【 分 子 量 】644.73382 |
【开发单位】University of Texas System (Originator) 【药理作用】ONCOLYTIC DRUGS, DNA-Intercalating Drugs, Telomerase Inhibitors |
合成路线1
The title bis-imide was synthesized by condensation of 3,4,9,10-perylenetetracarboxylic acid dianhydride (I) with N-(3-aminopropyl)morpholine (II) in hot n-butanol.
| 【1】 Kerwin, S.M.; et al.; G-quadruplex DNA binding selectivity of perylenetetracarboxylic acid diimides is PH dependent and mediated by ligand aggregation. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 142. |
| 【2】 Salazar, M.; Kerwin, S.M.; Hurley, L.H.; Fedoroff, O.Y. (University of Texas System); Inhibition of human telomerase by a G-quadruplex-interaction cpd.. US 6156763; WO 9940087 . |
Extended Information