4-amino-N-[(1S)-2-amino-1-(4-chlorobenzyl)-2-oxoethyl]-8-chromanecarboxamide -Drug Synthesis Database

【结构式】

【分子编号】52006

【品名】4-amino-N-[(1S)-2-amino-1-(4-chlorobenzyl)-2-oxoethyl]-8-chromanecarboxamide

【CA登记号】

【分子式】C₁₉H₂₀ClN₃O₃

【分子量】373.83892

【元素组成】C 61.04% H 5.39% Cl 9.48% N 11.24% O 12.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The target compound has been obtained by reductocondensation of 1-(4-cyanobenzyl)-1H-imidazole-5-carbaldehyde (I) with N2-(4-amino-3,4-dihydro-2H-1-benzopyran-8-ylcarbonyl)-4-chlorophenylalaninamide (II) by means of NaBH3CN and HOAc in acetonitrile.

参考文献中间体

合成目标

【1】 Jimonet, P.; Dereu, N.; Le Brun, A.; Baudoin, B.; Clerc, F.; El-Ahmad, Y.; Hardy, J.-C. (Aventis Pharma SA); Condensed heterocyclic system derivs., preparation, pharmaceutical compsns. containing them. EP 1054882; FR 2774987; WO 9941248 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	38388	4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile		C₁₂H₉N₃O	详情	详情
(II)	52006	4-amino-N-[(1S)-2-amino-1-(4-chlorobenzyl)-2-oxoethyl]-8-chromanecarboxamide		C₁₉H₂₀ClN₃O₃	详情	详情

Extended Information