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【结 构 式】 
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【药物名称】RPR-201764 【化学名称】4-Chloro-N-[4-[1-(4-cyanobenzyl)-1H-imidazol-5-ylmethylamino]-1-benzopyran-8-ylcarbonyl]-L-phenylalaninamide 【CA登记号】238764-04-0, 238763-08-1 (diastereomer), 238763-09-2 (diastereomer) 【 分 子 式 】C31H29ClN6O3 【 分 子 量 】569.06818 |
【开发单位】Aventis Pharma (Originator) 【药理作用】ONCOLYTIC DRUGS, Farnesyl Transferase Inhibitors, Inhibitors of Signal Transduction Pathways |
合成路线1
The target compound has been obtained by reductocondensation of 1-(4-cyanobenzyl)-1H-imidazole-5-carbaldehyde (I) with N2-(4-amino-3,4-dihydro-2H-1-benzopyran-8-ylcarbonyl)-4-chlorophenylalaninamide (II) by means of NaBH3CN and HOAc in acetonitrile.
| 【1】 Jimonet, P.; Dereu, N.; Le Brun, A.; Baudoin, B.; Clerc, F.; El-Ahmad, Y.; Hardy, J.-C. (Aventis Pharma SA); Condensed heterocyclic system derivs., preparation, pharmaceutical compsns. containing them. EP 1054882; FR 2774987; WO 9941248 . |
Extended Information