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【结 构 式】 
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【分子编号】51696 【品名】2-(2,3-dihydro-1H-inden-2-ylamino)acetamide 【CA登记号】 |
【 分 子 式 】C11H14N2O 【 分 子 量 】190.24504 【元素组成】C 69.45% H 7.42% N 14.72% O 8.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The reductive condensation between 2-indanone (I) and glycine methyl ester (II) in the presence of sodium cyanoborohydride furnished methyl (2-indanylamino)acetate (III). Subsequent ammonolysis of the methyl ester group of (III) in methanolic ammonia gave the glycinamide derivative (IV), which was finally converted to the title hydrochloride salt.
| 【1】 Chiesi, P.; Ventura, P.; Delcanale, M.; De Fanti, R.; Armani, E.; Villetti, G.; Pietra, C. (Chiesi Farmaceutici SpA); alpha-Amino acid amides, preparation thereof and the therapeutical use thereof. EP 0951465; JP 2001506577; US 6114391; WO 9803472 . |
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