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【结 构 式】 
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【药物名称】CHF-3381 【化学名称】N-(2-Indanyl)glycinamide hydrochloride 【CA登记号】202914-18-9, 202844-10-8 (free base) 【 分 子 式 】C11H15ClN2O 【 分 子 量 】226.708 |
【开发单位】Chiesi (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Neuropathic Pain, Treatment of, MAO Inhibitors, NMDA Antagonists |
合成路线1
The reductive condensation between 2-indanone (I) and glycine methyl ester (II) in the presence of sodium cyanoborohydride furnished methyl (2-indanylamino)acetate (III). Subsequent ammonolysis of the methyl ester group of (III) in methanolic ammonia gave the glycinamide derivative (IV), which was finally converted to the title hydrochloride salt.
| 【1】 Chiesi, P.; Ventura, P.; Delcanale, M.; De Fanti, R.; Armani, E.; Villetti, G.; Pietra, C. (Chiesi Farmaceutici SpA); alpha-Amino acid amides, preparation thereof and the therapeutical use thereof. EP 0951465; JP 2001506577; US 6114391; WO 9803472 . |
Extended Information