3-benzoyl-4-hydroxy-1-phenyl[1,8]naphthyridin-2(1H)-one -Drug Synthesis Database

【结构式】

【分子编号】51629

【品名】3-benzoyl-4-hydroxy-1-phenyl[1,8]naphthyridin-2(1H)-one

【CA登记号】

【分子式】C₂₁H₁₄N₂O₃

【分子量】342.35384

【元素组成】C 73.68% H 4.12% N 8.18% O 14.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Friedel-Crafts acylation of 4-hydroxy-1-phenyl[1,8]naphthyridin-2(1H)-one (I) with benzoyl chloride (II) using AlCl3 in hot nitrobenzene produced the 3-benzoyl naphthyridinone (III). This was cyclized to the title pyrazolonaphthyridinone by treatment with hydrazine in refluxing HOAc.

参考文献中间体

合成目标

【1】 Suzuki, F.; Kawakita, T.; Kuroda, T.; Ohmori, K.; Nakajima, H.; Kamiya, T.; Tamaoki, T. (Kyowa Hakko Kogyo Co., Ltd.); Condensed naphthyridine derivs.. EP 0526840; JP 1993194515; US 5281610 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12018	4-Hydroxy-1-phenyl[1,8]naphthyridin-2(1H)-one		C₁₄H₁₀N₂O₂	详情	详情
(II)	10463	Benzoyl chloride	98-88-4	C₇H₅ClO	详情	详情
(III)	51629	3-benzoyl-4-hydroxy-1-phenyl[1,8]naphthyridin-2(1H)-one		C₂₁H₁₄N₂O₃	详情	详情

Extended Information