【结 构 式】 |
【药物名称】KF-19418 【化学名称】3,5-Diphenyl-4,5-dihydro-1H-pyrazolo[4,3-c][1,8]naphthyridin-4-one 【CA登记号】147508-06-3 【 分 子 式 】C21H14N4O 【 分 子 量 】338.37193 |
【开发单位】Kyowa Hakko (Originator) 【药理作用】DERMATOLOGIC DRUGS, Hair Growth Stimulants |
合成路线1
Friedel-Crafts acylation of 4-hydroxy-1-phenyl[1,8]naphthyridin-2(1H)-one (I) with benzoyl chloride (II) using AlCl3 in hot nitrobenzene produced the 3-benzoyl naphthyridinone (III). This was cyclized to the title pyrazolonaphthyridinone by treatment with hydrazine in refluxing HOAc.
【1】 Suzuki, F.; Kawakita, T.; Kuroda, T.; Ohmori, K.; Nakajima, H.; Kamiya, T.; Tamaoki, T. (Kyowa Hakko Kogyo Co., Ltd.); Condensed naphthyridine derivs.. EP 0526840; JP 1993194515; US 5281610 . |
Extended Information