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【结 构 式】 
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【分子编号】51496 【品名】3-Aminobenzoylmethylamide 【CA登记号】25900-61-2 |
【 分 子 式 】C8H10N2O 【 分 子 量 】150.18028 【元素组成】C 63.98% H 6.71% N 18.65% O 10.65% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)2-Naphthylacetic acid (I) was converted to the corresponding acid chloride (II) upon treatment with oxalyl chloride in the presence of a catalytic amount of DMF. Subsequent coupling of acid chloride (II) with N-methyl-3-aminobenzamide (III) in pyridine furnished the target diamide.
| 【1】 Kawamura, M.; Ando, R.; Chiba, N.; 3-(Arylacetylamino)-N-methylbenzamides: A novel class of selective anti-Helicobacter pylori agents. J Med Chem 2001, 44, 25, 4468. |
| 【2】 Ando, R.; et al.; 3-(Arylacetylamino)-N-methylbenzamides: New class of selective anti-Helicobacter pylori agents. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 248. |
| 【3】 Ando, R.; Watanabe, K.; Chiba, N.; Kawamura, M. (Mitsubishi Chemical Corp.); Amide derivs.. EP 0887341; JP 1999071336 . |
Extended Information