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【结 构 式】 
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【药物名称】BAS-118 【化学名称】N-Methyl-3-[2-(2-naphthyl)acetamido]benzamide 【CA登记号】 【 分 子 式 】C20H18N2O2 【 分 子 量 】318.37866 |
【开发单位】Mitsubishi Chemical (Originator) 【药理作用】Anti-Helicobacter Pylori Agents, Antiulcer Drugs, GASTROINTESTINAL DRUGS |
合成路线1
2-Naphthylacetic acid (I) was converted to the corresponding acid chloride (II) upon treatment with oxalyl chloride in the presence of a catalytic amount of DMF. Subsequent coupling of acid chloride (II) with N-methyl-3-aminobenzamide (III) in pyridine furnished the target diamide.
| 【1】 Kawamura, M.; Ando, R.; Chiba, N.; 3-(Arylacetylamino)-N-methylbenzamides: A novel class of selective anti-Helicobacter pylori agents. J Med Chem 2001, 44, 25, 4468. |
| 【2】 Ando, R.; et al.; 3-(Arylacetylamino)-N-methylbenzamides: New class of selective anti-Helicobacter pylori agents. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 248. |
| 【3】 Ando, R.; Watanabe, K.; Chiba, N.; Kawamura, M. (Mitsubishi Chemical Corp.); Amide derivs.. EP 0887341; JP 1999071336 . |
Extended Information