5-carboxy-2-chloro-1-pyridiniumolate -Drug Synthesis Database

【结构式】

【分子编号】51116

【品名】5-carboxy-2-chloro-1-pyridiniumolate

【CA登记号】

【分子式】C₆H₄ClNO₃

【分子量】173.5554

【元素组成】C 41.52% H 2.32% Cl 20.43% N 8.07% O 27.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

6-Chloronicotinic acid (I) was converted to the corresponding N-oxide (II) using trifluoroperacetic acid. Acid (II) was subsequently condensed with 4-fluoroaniline (III) using EEDQ as the coupling reagent to provide the target amide.

参考文献中间体

合成目标

【1】 Cutshall, N.S.; et al.; Nicotinamide N-oxides as CXCR2 antagonists. Bioorg Med Chem Lett 2001, 11, 14, 1951.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12996	6-Chloronicotinic acid	5326-23-8	C₆H₄ClNO₂	详情	详情
(II)	51116	5-carboxy-2-chloro-1-pyridiniumolate		C₆H₄ClNO₃	详情	详情
(III)	37698	3-ethyl-2-oxatricyclo[3.3.1.1(3,7)]decan-1-ol		C₁₁H₁₈O₂	详情	详情

Extended Information