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【结 构 式】 
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【药物名称】 【化学名称】6-Chloro-N-(4-fluorophenyl)pyridine-3-carboxamide 1-oxide 【CA登记号】 【 分 子 式 】C12H8ClFN2O2 【 分 子 量 】266.66116 |
【开发单位】Celltech (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Antiarthritic Drugs, Antipsoriatics, Asthma Therapy, DERMATOLOGIC DRUGS, RESPIRATORY DRUGS, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Chemokine CXCR2 (IL-8 beta Receptor) Antagonists |
合成路线1
6-Chloronicotinic acid (I) was converted to the corresponding N-oxide (II) using trifluoroperacetic acid. Acid (II) was subsequently condensed with 4-fluoroaniline (III) using EEDQ as the coupling reagent to provide the target amide.
| 【1】 Cutshall, N.S.; et al.; Nicotinamide N-oxides as CXCR2 antagonists. Bioorg Med Chem Lett 2001, 11, 14, 1951. |
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