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【结 构 式】 
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【分子编号】50919 【品名】3-chloro-N-hydroxy-N-(2-propynyl)propanamide 【CA登记号】 |
【 分 子 式 】C6H8ClNO2 【 分 子 量 】161.58776 【元素组成】C 44.6% H 4.99% Cl 21.94% N 8.67% O 19.8% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Alkylation of hydroxylamine with propargyl bromide (I) provided N-propargyl hydroxylamine (II), which was subsequently acylated with 3-chloropropionyl chloride (III) in the presence of pyridine to yield the N-hydroxy amide (IV). Mannich reaction of the propargyl compound (IV) with paraformaldehyde and pyrrolidine (V) with simultaneous cyclization of the N-hydroxy chloropropionamide furnished the title compound.
| 【1】 Amstutz, R.; et al.; Position 5 at the oxotremorinic skeleton as the stearing position for activity at the muscarinic receptors. Helv Chim Acta 1987, 70, 2232. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11176 | 3-Bromopropyne; 3-Bromo-1-propyne | 106-96-7 | C3H3Br | 详情 | 详情 |
| (II) | 50918 | 3-(hydroxyamino)-1-propyne; N-(2-propynyl)hydroxylamine | C3H5NO | 详情 | 详情 | |
| (III) | 18935 | 3,4-dimethoxyphenylamine; 3,4-dimethoxyaniline | 6315-89-5 | C8H11NO2 | 详情 | 详情 |
| (IV) | 50919 | 3-chloro-N-hydroxy-N-(2-propynyl)propanamide | C6H8ClNO2 | 详情 | 详情 | |
| (V) | 11376 | Pyrrolidine | 123-75-1 | C4H9N | 详情 | 详情 |
Extended Information