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【结 构 式】 
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【药物名称】 【化学名称】2-[4-(1-Pyrrolidinyl)-2-butynyl]isoxazolidin-3-one 【CA登记号】116445-17-1 【 分 子 式 】C11H16N2O2 【 分 子 量 】208.26237 |
【开发单位】Università degli Studi di Milano (Originator), Università degli Studi di Parma (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics, Muscarinic M1 Agonists, Muscarinic M2 Agonists, Muscarinic M3 Agonists |
合成路线1
Alkylation of hydroxylamine with propargyl bromide (I) provided N-propargyl hydroxylamine (II), which was subsequently acylated with 3-chloropropionyl chloride (III) in the presence of pyridine to yield the N-hydroxy amide (IV). Mannich reaction of the propargyl compound (IV) with paraformaldehyde and pyrrolidine (V) with simultaneous cyclization of the N-hydroxy chloropropionamide furnished the title compound.
| 【1】 Amstutz, R.; et al.; Position 5 at the oxotremorinic skeleton as the stearing position for activity at the muscarinic receptors. Helv Chim Acta 1987, 70, 2232. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11176 | 3-Bromopropyne; 3-Bromo-1-propyne | 106-96-7 | C3H3Br | 详情 | 详情 |
| (II) | 50918 | 3-(hydroxyamino)-1-propyne; N-(2-propynyl)hydroxylamine | C3H5NO | 详情 | 详情 | |
| (III) | 18935 | 3,4-dimethoxyphenylamine; 3,4-dimethoxyaniline | 6315-89-5 | C8H11NO2 | 详情 | 详情 |
| (IV) | 50919 | 3-chloro-N-hydroxy-N-(2-propynyl)propanamide | C6H8ClNO2 | 详情 | 详情 | |
| (V) | 11376 | Pyrrolidine | 123-75-1 | C4H9N | 详情 | 详情 |
合成路线2
In an alternative procedure, nucleophilic displacement of the nitro group from 3-nitro-2-isoxazoline (VI) with lithium benzylate gave the benzyl ether (VII), which was converted to isoxazolidinone (VIII) by catalytic hydrogenation. Alkylation of (VIII) with 1,4-dichloro-2-butyne (IX) resulted in a 4:1 mixture of regioisomers (X) and (XI). After chromatographic isolation, the desired isomer (X) was condensed with pyrrolidine (V) to provide the title compound.
| 【1】 Dallanoce, C.; et al.; Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M. Bioorg Med Chem 1999, 7, 8, 1539. |
| 【2】 Conti, P.; et al.; Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine. Bioorg Med Chem Lett 1997, 7, 8, 1033. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 50920 | 3-nitro-4,5-dihydroisoxazole | C3H4N2O3 | 详情 | 详情 | |
| (VII) | 50921 | benzyl 4,5-dihydro-3-isoxazolyl ether; 3-(benzyloxy)-4,5-dihydroisoxazole | C10H11NO2 | 详情 | 详情 | |
| (VIII) | 50922 | 3-isoxazolidinone | C3H5NO2 | 详情 | 详情 | |
| (IX) | 50923 | 1,4-Dichloro-2-butyne | 821-10-3 | C4H4Cl2 | 详情 | 详情 |
| (X) | 50924 | 2-(4-chloro-2-butynyl)-3-isoxazolidinone | C7H8ClNO2 | 详情 | 详情 | |
| (XI) | 50925 | 3-[(4-chloro-2-butynyl)oxy]-4,5-dihydroisoxazole; 4-chloro-2-butynyl 4,5-dihydro-3-isoxazolyl ether | C7H8ClNO2 | 详情 | 详情 |