2-(1-methyl-2-phenyl-1H-indol-3-yl)acetic acid -Drug Synthesis Database

【结构式】

【分子编号】50897

【品名】2-(1-methyl-2-phenyl-1H-indol-3-yl)acetic acid

【CA登记号】

【分子式】C₁₇H₁₅NO₂

【分子量】265.31164

【元素组成】C 76.96% H 5.7% N 5.28% O 12.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Reductive amination of pyridine-4-carbaldehyde (I) with isopropylamine (II) in the presence of NaBH4 furnished the secondary amine (III). This was then acylated with the indoleacetic acid (IV) using PyBOP as the coupling reagent to yield the target amide.

参考文献中间体

合成目标

【1】 Lumma, W.C.; Quigley, A.G.; Sisko, J.T.; et al.; 2-Arylindole-3-acetamides as FPP-competitive inhibitors of farnesyltransferase. 221st ACS Natl Meet (April 1 2001, San Diego) 2001, Abst MEDI 154.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17203	4-Pyridinecarboxaldehyde; isonicotinaldehyde	872-85-5	C₆H₅NO	详情	详情
(II)	23933	2-Propanamine; Isopropylamine	75-31-0	C₃H₉N	详情	详情
(III)	50896	N-isopropyl-N-(4-pyridinylmethyl)amine; N-(4-pyridinylmethyl)-2-propanamine		C₉H₁₄N₂	详情	详情
(IV)	50897	2-(1-methyl-2-phenyl-1H-indol-3-yl)acetic acid		C₁₇H₁₅NO₂	详情	详情

Extended Information