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【结 构 式】

【分子编号】50896

【品名】N-isopropyl-N-(4-pyridinylmethyl)amine; N-(4-pyridinylmethyl)-2-propanamine

【CA登记号】

【 分 子 式 】C9H14N2

【 分 子 量 】150.22364

【元素组成】C 71.96% H 9.39% N 18.65%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Reductive amination of pyridine-4-carbaldehyde (I) with isopropylamine (II) in the presence of NaBH4 furnished the secondary amine (III). This was then acylated with the indoleacetic acid (IV) using PyBOP as the coupling reagent to yield the target amide.

1 Lumma, W.C.; Quigley, A.G.; Sisko, J.T.; et al.; 2-Arylindole-3-acetamides as FPP-competitive inhibitors of farnesyltransferase. 221st ACS Natl Meet (April 1 2001, San Diego) 2001, Abst MEDI 154.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 17203 4-Pyridinecarboxaldehyde; isonicotinaldehyde 872-85-5 C6H5NO 详情 详情
(II) 23933 2-Propanamine; Isopropylamine 75-31-0 C3H9N 详情 详情
(III) 50896 N-isopropyl-N-(4-pyridinylmethyl)amine; N-(4-pyridinylmethyl)-2-propanamine C9H14N2 详情 详情
(IV) 50897 2-(1-methyl-2-phenyl-1H-indol-3-yl)acetic acid C17H15NO2 详情 详情
Extended Information