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【结 构 式】 
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【分子编号】50159 【品名】N(1)-[(E)-[10-([[3-(dimethylamino)propyl]imino]methyl)dibenzo[b,j][1,7]phenanthrolin-2-yl]methylidene]-N(3),N(3)-dimethyl-1,3-propanediamine; N-[3-(dimethylamino)propyl]-N-[(E)-[10-([[3-(dimethylamino)propyl]imino]methyl)dibenzo[b,j][1,7]phenanthrolin-2-yl]methylidene]amine 【CA登记号】 |
【 分 子 式 】C32H36N6 【 分 子 量 】504.67828 【元素组成】C 76.16% H 7.19% N 16.65% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The title compound was prepared starting from dibenzo[b,j](1,7)phenanthroline-2,10-dicarboxaldehyde (I). Condensation of dialdehyde (I) with 3-(dimethylamino)propylamine (II) produced the intermediate diimine (III), which was then reduced to the corresponding amine by using NaBH4 in MeOH.
| 【1】 Lacroix, L.; Mergny, J.-L.; Teulade-Frchou, M.-P.; et al.; Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay. Proc Natl Acad Sci USA 2001, 98, 6, 3062. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 50158 | dibenzo[b,j][1,7]phenanthroline-2,10-dicarbaldehyde | C22H12N2O2 | 详情 | 详情 | |
| (II) | 25248 | N-(3-aminopropyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,3-propanediamine | 109-55-7 | C5H14N2 | 详情 | 详情 |
| (III) | 50159 | N(1)-[(E)-[10-([[3-(dimethylamino)propyl]imino]methyl)dibenzo[b,j][1,7]phenanthrolin-2-yl]methylidene]-N(3),N(3)-dimethyl-1,3-propanediamine; N-[3-(dimethylamino)propyl]-N-[(E)-[10-([[3-(dimethylamino)propyl]imino]methyl)dibenzo[b,j][1,7]phenanthrolin-2-yl]methylidene]amine | C32H36N6 | 详情 | 详情 |
Extended Information