dibenzo[b,j][1,7]phenanthroline-2,10-dicarbaldehyde -Drug Synthesis Database

【结构式】

【分子编号】50158

【品名】dibenzo[b,j][1,7]phenanthroline-2,10-dicarbaldehyde

【CA登记号】

【分子式】C₂₂H₁₂N₂O₂

【分子量】336.34956

【元素组成】C 78.56% H 3.6% N 8.33% O 9.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title compound was prepared starting from dibenzo[b,j](1,7)phenanthroline-2,10-dicarboxaldehyde (I). Condensation of dialdehyde (I) with 3-(dimethylamino)propylamine (II) produced the intermediate diimine (III), which was then reduced to the corresponding amine by using NaBH4 in MeOH.

参考文献中间体

合成目标

【1】 Lacroix, L.; Mergny, J.-L.; Teulade-Frchou, M.-P.; et al.; Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay. Proc Natl Acad Sci USA 2001, 98, 6, 3062.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	50158	dibenzo[b,j][1,7]phenanthroline-2,10-dicarbaldehyde		C₂₂H₁₂N₂O₂	详情	详情
(II)	25248	N-(3-aminopropyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,3-propanediamine	109-55-7	C₅H₁₄N₂	详情	详情
(III)	50159	N(1)-[(E)-[10-([[3-(dimethylamino)propyl]imino]methyl)dibenzo[b,j][1,7]phenanthrolin-2-yl]methylidene]-N(3),N(3)-dimethyl-1,3-propanediamine; N-[3-(dimethylamino)propyl]-N-[(E)-[10-([[3-(dimethylamino)propyl]imino]methyl)dibenzo[b,j][1,7]phenanthrolin-2-yl]methylidene]amine		C₃₂H₃₆N₆	详情	详情

Extended Information