methyl 1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-5-yl sulfide; 1-methyl-5-(methylsulfanyl)-2,3-dihydro-1H-1,4-benzodiazepine -Drug Synthesis Database

【结构式】

【分子编号】50129

【品名】methyl 1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-5-yl sulfide; 1-methyl-5-(methylsulfanyl)-2,3-dihydro-1H-1,4-benzodiazepine

【CA登记号】

【分子式】C₁₁H₁₄N₂S

【分子量】206.31164

【元素组成】C 64.04% H 6.84% N 13.58% S 15.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The known (methylmercapto)benzodiazepine (I) was condensed with isonicotinic hydrazide (II) in refluxing EtOH to give the intermediate hydrazinobenzodiazepine (III), which under the reaction conditions cyclized to the target triazolobenzodiazepine.

参考文献中间体

合成目标

【1】 Vega, S.; Madronero, R.; Synthesis of triazolo[4,3-d]-, tetrazolo[1,5-a]- and quinazolino[3,2-d] [1,4]benzodiazepines. J Heterocycl Chem 1978, 15, 7, 1127.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	50129	methyl 1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-5-yl sulfide; 1-methyl-5-(methylsulfanyl)-2,3-dihydro-1H-1,4-benzodiazepine		C₁₁H₁₄N₂S	详情	详情
(II)	26079	Isonicotinohydrazide	54-85-3	C₆H₇N₃O	详情	详情
(III)	50130	N'-(1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-5-yl)isonicotinohydrazide		C₁₆H₁₇N₅O	详情	详情

Extended Information