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【结 构 式】 
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【药物名称】 【化学名称】7-Methyl-3-(4-pyridyl)-6,7-dihydro-5H-[1,2,4]triazolo[4,3-d][1,4]benzodiazepine 【CA登记号】 【 分 子 式 】C16H15N5 【 分 子 量 】277.33145 |
【开发单位】CSIC (Originator), Universidad de La Laguna (Originator) 【药理作用】Antidepressants, Antiepileptic Drugs, Anxiolytics, Mood Disorders, Treatment of, NEUROLOGIC DRUGS, PSYCHOPHARMACOLOGIC DRUGS, Sedative/Hypnotics, Sleep Disorders, Treatment of |
合成路线1
The known (methylmercapto)benzodiazepine (I) was condensed with isonicotinic hydrazide (II) in refluxing EtOH to give the intermediate hydrazinobenzodiazepine (III), which under the reaction conditions cyclized to the target triazolobenzodiazepine.
| 【1】 Vega, S.; Madronero, R.; Synthesis of triazolo[4,3-d]-, tetrazolo[1,5-a]- and quinazolino[3,2-d] [1,4]benzodiazepines. J Heterocycl Chem 1978, 15, 7, 1127. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 50129 | methyl 1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-5-yl sulfide; 1-methyl-5-(methylsulfanyl)-2,3-dihydro-1H-1,4-benzodiazepine | C11H14N2S | 详情 | 详情 | |
| (II) | 26079 | Isonicotinohydrazide | 54-85-3 | C6H7N3O | 详情 | 详情 |
| (III) | 50130 | N'-(1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-5-yl)isonicotinohydrazide | C16H17N5O | 详情 | 详情 |
Extended Information