(2R,3R)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol trihydrochloride -Drug Synthesis Database

【结构式】

【分子编号】66122

【品名】(2R,3R)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol trihydrochloride

【CA登记号】　

【分子式】C₂₂H₂₉Cl₃N₄O

【分子量】471.857

【元素组成】C 56.00% H 6.19% Cl 22.54% N 11.87% O 3.39%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXI)

【1】 Fassler A, Bold G, Capraro H, et aL 1996. Aza-peptide analogs as potent human immunodeficiency virus type-l protease inhibitors with oral bioavailability.JMed Cha;n, 39, 3203一3216
【2】 Fassler A, Bold G, Capraro H, et aL 1997. lruermediates Ior the prepantion of peptide analogues, W0 9746514
【3】 Giordano C, Pozzoli C, Benedetti F.2001. Ptocess for the pr帕嘣tion可8ryl-pyritlinyl compounds, W0 012083

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22231	4-Bromobenzaldehyde	1122-91-4	C₇H₅BrO	详情	详情
(II)	23438	(4-bromophenyl)(methoxy)methyl methyl ether; 1-bromo-4-(dimethoxymethyl)benzene		C₉H₁₁BrO₂	详情	详情
(III)	29052	2-Bromopyridine；α-bromopyridine;α-bromoazine	109-04-6	C₅H₄BrN	详情	详情
(IV)	23440	4-(2-pyridinyl)benzaldehyde		C₁₂H₉NO	详情	详情
(V)	10893	tert-butyl 1-hydrazinecarboxylate; tert-butyl carbazate	870-46-2	C₅H₁₂N₂O₂	详情	详情
(VI)	23442	tert-butyl 2-[(Z)-[4-(2-pyridinyl)phenyl]methylidene]-1-hydrazinecarboxylate		C₁₇H₁₉N₃O₂	详情	详情
(VII)	23452	tert-butyl (1S)-1-benzyl-2-oxoethylcarbamate		C₁₄H₁₉NO₃	详情	详情
(VIII)	23444	tert-butyl (1S)-1-[(2R)oxiranyl]-2-phenylethylcarbamate		C₁₅H₂₁NO₃	详情	详情
(XXI)	66122	(2R,3R)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol trihydrochloride		C₂₂H₂₉Cl₃N₄O	详情	详情
(XXII)	66123	1,1,3,3-tetramethyl-2-(2-oxopiperidin-1-yl)isouronium tetrafluoroborate		C₁₀H₂₀F₄N₃O₂	详情	详情

Extended Information