【结 构 式】 ![]() |
【分子编号】66090 【品名】(R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline 【CA登记号】 |
【 分 子 式 】C19H21NO2 【 分 子 量 】295.38128 【元素组成】C 77.26% H 7.17% N 4.74% O 10.83% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号:(X)
【1】 Shi XX, Ni F,Shang HX et al.2006. Racemization of(S)一(+)一10,11-dimethoxyaporphine ancl(S)一(+)一 aporphine, efficient preparations of(R)-(-)-apomorphine and(R)一(一)一aporplune via a recycle process of relolution etrahedran Asymm,7(15): 2210-2215 |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VII) | 66087 | (S)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 | |
(VIII) | 66088 | 10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 | |
(IX) | 66089 | (2S,3S)-2,3-bis(benzoyloxy)butanedioic acid | 17026-42-5 | C18H14O8 | 详情 | 详情 |
(X) | 66090 | (R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(X)
【1】 Shi XX.NiF.Shang HX,et aL 2005.Prepantion for (R)-(-)-apomorpIune used in merhcines for treating Parkinson disease and ED发明专利申请说明书,CN 1680330 |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VIII) | 66088 | 10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 | |
(IX) | 66089 | (2S,3S)-2,3-bis(benzoyloxy)butanedioic acid | 17026-42-5 | C18H14O8 | 详情 | 详情 |
(X) | 66090 | (R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 | |
(XI) | 66091 | 1-(chloromethyl)-3,4-dimethoxy-2-nitrobenzene | C9H10ClNO4 | 详情 | 详情 | |
(XII) | 66092 | (1-methylcinnolin-2(1H)-yl)(phenyl)methanone | C16H14N2O | 详情 | 详情 | |
(XIII) | 66093 | 1-(3,4-dimethoxy-2-nitrobenzyl)isoquinoline | C18H16N2O4 | 详情 | 详情 | |
(XIV) | 66094 | 1-(3,4-dimethoxy-2-nitrobenzyl)-2-methylisoquinolin-2-ium iodide | C19H19IN2O4 | 详情 | 详情 | |
(XV) | 66079 | 1-(3,4-dimethoxy-2-nitrobenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | C19H22N2O4 | 详情 | 详情 | |
(XVI) | 66080 | 2,3-dimethoxy-6-((2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)aniline | C19H24N2O2 | 详情 | 详情 |
Extended Information