Apomorphine Hydrochloride, -Drug Synthesis Database

【结构式】

【药物名称】Apomorphine Hydrochloride

【化学名称】(R)-6-methyl-5,6,6a,7-hexahydro-4H-dibenzo[de,g]quinoline-10,11-diol Hydrochloride Hemihydrate

【CA登记号】41372-20-7

【分子式】C₁₇H₁₇NO₂

【分子量】287.32

【开发单位】Bertek

【药理作用】抗震颤麻痹药

【1】 Ram VJ, Neumeyer JL 1981. Aporphines 35.synthesis of（R)-(一）一and(S)一(+)-apomorphine from thebaine and (+)-BulbocapnineJ Org Cbem, 46. 2831---2833

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66081	(4S)-7,9-dimethoxy-3,4-dimethyl-2,3,4,4a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline		C₂₀H₂₃NO₃	详情	详情
(II)	66082	(S)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,11-diol		C₁₈H₁₉NO₃	详情	详情
(III)	66083	(6aS)-6-methyl-3a1,4,5,6,6a,7-hexahydro-3aH-dibenzo[de,g]quinoline-2,10,11-triol	77630-01-4	C₁₇H₁₇NO₃	详情	详情
(IV)	66084	1H-Tetrazole,5-chloro-1-phenyl-;1-Phenyl-5-chlorotetrazole;5-Chloro-1-phenyl-1H-tetrazole; 5-Chloro-1-phenyltetrazole;N-Phenyl-5-chlorotetrazole	14210-25-4	C₇H₅ClN₄	详情	详情
(V)	66085	(6aS)-7-methyl-6a,6a1,7,8,9,9a-hexahydro-6H-[1,3]dioxolo[4',5':5,6]benzo[1,2-g]benzo[de]quinoline		C₁₈H₁₇NO₂	详情	详情
(VI)	66086	(6aS)-6-methyl-3a1,4,5,6,6a,7-hexahydro-3aH-dibenzo[de,g]quinoline-10,11-diol	58-00-4	C₁₇H₁₇NO₂	详情	详情

【1】 Shi XX, Ni F，Shang HX et al.2006. Racemization of(S)一(+)一10，11-dimethoxyaporphine ancl(S)一(+)一 aporphine, efficient preparations of(R)-(-)-apomorphine and(R)一（一）一aporplune via a recycle process of relolution etrahedran Asymm,7(15): 2210-2215

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VII)	66087	(S)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline		C₁₉H₂₁NO₂	详情	详情
(VIII)	66088	10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline		C₁₉H₂₁NO₂	详情	详情
(IX)	66089	(2S,3S)-2,3-bis(benzoyloxy)butanedioic acid	17026-42-5	C₁₈H₁₄O₈	详情	详情
(X)	66090	(R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline		C₁₉H₂₁NO₂	详情	详情

【1】 Shi XX.NiF.Shang HX,et aL 2005.Prepantion for (R)-(-)-apomorpIune used in merhcines for treating Parkinson disease and ED发明专利申请说明书，CN 1680330

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VIII)	66088	10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline		C₁₉H₂₁NO₂	详情	详情
(IX)	66089	(2S,3S)-2,3-bis(benzoyloxy)butanedioic acid	17026-42-5	C₁₈H₁₄O₈	详情	详情
(X)	66090	(R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline		C₁₉H₂₁NO₂	详情	详情
(XI)	66091	1-(chloromethyl)-3,4-dimethoxy-2-nitrobenzene		C₉H₁₀ClNO₄	详情	详情
(XII)	66092	(1-methylcinnolin-2(1H)-yl)(phenyl)methanone		C₁₆H₁₄N₂O	详情	详情
(XIII)	66093	1-(3,4-dimethoxy-2-nitrobenzyl)isoquinoline		C₁₈H₁₆N₂O₄	详情	详情
(XIV)	66094	1-(3,4-dimethoxy-2-nitrobenzyl)-2-methylisoquinolin-2-ium iodide		C₁₉H₁₉IN₂O₄	详情	详情
(XV)	66079	1-(3,4-dimethoxy-2-nitrobenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline		C₁₉H₂₂N₂O₄	详情	详情
(XVI)	66080	2,3-dimethoxy-6-((2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)aniline		C₁₉H₂₄N₂O₂	详情	详情

【1】 Csutoras C, BerenyiS.Makleit S 1996.Anew and efficient one-pot synthesis of apomorplune and its ring-A halogenated derivatives. Synth Commun, 26 (12)1 2251---2266

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XVII)	66095	(4R,7aS,12bS)-9-methoxy-3,7a-dimethyl-2,3,4,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline		C₁₉H₂₁NO₂	详情	详情

Extended Information

FDA Approved Drug Products(3)