【结 构 式】 ![]() |
【药物名称】Apomorphine Hydrochloride 【化学名称】(R)-6-methyl-5,6,6a,7-hexahydro-4H-dibenzo[de,g]quinoline-10,11-diol Hydrochloride Hemihydrate 【CA登记号】41372-20-7 【 分 子 式 】C17H17NO2 【 分 子 量 】287.32 |
【开发单位】Bertek 【药理作用】抗震颤麻痹药 |
合成路线1
【1】 Ram VJ, Neumeyer JL 1981. Aporphines 35.synthesis of(R)-(一)一and(S)一(+)-apomorphine from thebaine and (+)-BulbocapnineJ Org Cbem, 46. 2831---2833 |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 66081 | (4S)-7,9-dimethoxy-3,4-dimethyl-2,3,4,4a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline | C20H23NO3 | 详情 | 详情 | |
(II) | 66082 | (S)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,11-diol | C18H19NO3 | 详情 | 详情 | |
(III) | 66083 | (6aS)-6-methyl-3a1,4,5,6,6a,7-hexahydro-3aH-dibenzo[de,g]quinoline-2,10,11-triol | 77630-01-4 | C17H17NO3 | 详情 | 详情 |
(IV) | 66084 | 1H-Tetrazole,5-chloro-1-phenyl-;1-Phenyl-5-chlorotetrazole;5-Chloro-1-phenyl-1H-tetrazole; 5-Chloro-1-phenyltetrazole;N-Phenyl-5-chlorotetrazole | 14210-25-4 | C7H5ClN4 | 详情 | 详情 |
(V) | 66085 | (6aS)-7-methyl-6a,6a1,7,8,9,9a-hexahydro-6H-[1,3]dioxolo[4',5':5,6]benzo[1,2-g]benzo[de]quinoline | C18H17NO2 | 详情 | 详情 | |
(VI) | 66086 | (6aS)-6-methyl-3a1,4,5,6,6a,7-hexahydro-3aH-dibenzo[de,g]quinoline-10,11-diol | 58-00-4 | C17H17NO2 | 详情 | 详情 |
合成路线2
【1】 Shi XX, Ni F,Shang HX et al.2006. Racemization of(S)一(+)一10,11-dimethoxyaporphine ancl(S)一(+)一 aporphine, efficient preparations of(R)-(-)-apomorphine and(R)一(一)一aporplune via a recycle process of relolution etrahedran Asymm,7(15): 2210-2215 |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VII) | 66087 | (S)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 | |
(VIII) | 66088 | 10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 | |
(IX) | 66089 | (2S,3S)-2,3-bis(benzoyloxy)butanedioic acid | 17026-42-5 | C18H14O8 | 详情 | 详情 |
(X) | 66090 | (R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 |
合成路线3
【1】 Shi XX.NiF.Shang HX,et aL 2005.Prepantion for (R)-(-)-apomorpIune used in merhcines for treating Parkinson disease and ED发明专利申请说明书,CN 1680330 |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VIII) | 66088 | 10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 | |
(IX) | 66089 | (2S,3S)-2,3-bis(benzoyloxy)butanedioic acid | 17026-42-5 | C18H14O8 | 详情 | 详情 |
(X) | 66090 | (R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | C19H21NO2 | 详情 | 详情 | |
(XI) | 66091 | 1-(chloromethyl)-3,4-dimethoxy-2-nitrobenzene | C9H10ClNO4 | 详情 | 详情 | |
(XII) | 66092 | (1-methylcinnolin-2(1H)-yl)(phenyl)methanone | C16H14N2O | 详情 | 详情 | |
(XIII) | 66093 | 1-(3,4-dimethoxy-2-nitrobenzyl)isoquinoline | C18H16N2O4 | 详情 | 详情 | |
(XIV) | 66094 | 1-(3,4-dimethoxy-2-nitrobenzyl)-2-methylisoquinolin-2-ium iodide | C19H19IN2O4 | 详情 | 详情 | |
(XV) | 66079 | 1-(3,4-dimethoxy-2-nitrobenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | C19H22N2O4 | 详情 | 详情 | |
(XVI) | 66080 | 2,3-dimethoxy-6-((2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)aniline | C19H24N2O2 | 详情 | 详情 |
合成路线4
【1】 Csutoras C, BerenyiS.Makleit S 1996.Anew and efficient one-pot synthesis of apomorplune and its ring-A halogenated derivatives. Synth Commun, 26 (12)1 2251---2266 |
Extended Information