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【结 构 式】

【分子编号】49185

【品名】1-(5-fluoro-1-benzothiophen-2-yl)-3-[4-(2-methoxyphenyl)-1-piperazinyl]-1-propanone

【CA登记号】

【 分 子 式 】C22H23FN2O2S

【 分 子 量 】398.5013032

【元素组成】C 66.31% H 5.82% F 4.77% N 7.03% O 8.03% S 8.05%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Friedel-Crafts acylation of 5-fluorobenzothiophene (I) with 3-chloropropionyl chloride (II) in the presence of AlCl3 furnished the chloroketone (III). This was then condensed with N-(2-methoxyphenyl)piperazine (IV) to afford the piperazinyl ketone (V). Reduction of the keto group of (V) with NaBH4 then gave the title alcohol.

1 Martínez, J.; Oficialdegui, A.M.; Perez, S.; et al.; New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Eur J Med Chem 2001, 36, 1, 55.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 49183 5-fluoro-1-benzothiophene C8H5FS 详情 详情
(II) 18936 3-chloropropanoyl chloride 625-36-5 C3H4Cl2O 详情 详情
(III) 49184 3-chloro-1-(5-fluoro-1-benzothiophen-2-yl)-1-propanone C11H8ClFOS 详情 详情
(IV) 11882 1-(2-Methoxyphenyl)piperazine; Methyl 2-piperazinophenyl ether; 1-(2-Methoxyphenyl)-piperazine 35386-24-4 C11H16N2O 详情 详情
(V) 49185 1-(5-fluoro-1-benzothiophen-2-yl)-3-[4-(2-methoxyphenyl)-1-piperazinyl]-1-propanone C22H23FN2O2S 详情 详情
Extended Information