2-Fluoro-4-nitrobenzoic acid -Drug Synthesis Database

【结构式】

【分子编号】55903

【品名】2-Fluoro-4-nitrobenzoic acid

【CA登记号】403-24-7

【分子式】C₇H₄FNO₄

【分子量】185.1115032

【元素组成】C 45.42% H 2.18% F 10.26% N 7.57% O 34.57%

与该中间体有关的原料药合成路线共 3 条

合成路线1 合成路线2 合成路线3

合成路线1

该中间体在本合成路线中的序号：(II)

Jones oxidation of 2-fluoro-4-nitrotoluene (I) afforded carboxylic acid (II). After activation of (II) as the corresponding acid chloride with SOCl2, reaction with lithium tert-butoxide furnished the tert-butyl ester (III). Reduction of the nitro group of (III) by means of iron powder in the presence of ammonium chloride gave amine (IV), which was converted to carbamate (V) upon treatment with benzyl chloroformate. The chiral oxazolidinone (VII) was prepared by condensation of the lithium salt of carbamate (V) with (R)-glycidyl butyrate (VI). After activation of the primary hydroxyl of (VII) as the corresponding mesylate, displacement with NaN3 in hot DMF provided the alkyl azide (VIII). Tert-Butyl ester cleavage in (VIII) by means of trifluoroacetic acid afforded the carboxylic acid (IX). Curtius rearrangement of acid (IX) with diphenylphosphoryl azide in the presence of tert-butanol generated the tert-butyl carbamate (X). Further N-alkylation of carbamate (X) using iodomethane and LiH gave the N-methyl analogue (XI). Then, reduction of the azido group of (XI) to the primary amine (XII) was accomplished by treatment with triphenylphosphine followed by aqueous hydrolysis.

参考文献中间体

合成目标

【1】 Singh, U.; Gordeev, M.F.; Luehr, G.W.; Gadwood, R.C.; Jain, R.; Hackbarth, C.J.; Trias, J.; Patel, D.V.; Lopez, S.; Acyclic C-group oxazolidinones: Antimicrobial 4'-acylamino, 4'-urea and 4'-thiourea phenyloxazolidinones. 41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001, Chicago) 2001, Abst F-1045.
【2】 Patel, D.V.; Gadwood, R.C.; Gordeev, M.F.; Luehr, G.W. (Pharmacia Corp.); Oxazolidinones and their use as antiinfectives. EP 1200416; US 6441005; WO 0109107 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	55902	2-Fluoro-4-nitrotoluene; 4-Nitro-2-fluorotoluene	1427-07-2	C₇H₆FNO₂	详情	详情
(II)	55903	2-Fluoro-4-nitrobenzoic acid	403-24-7	C₇H₄FNO₄	详情	详情
(III)	55904	tert-butyl 2-fluoro-4-nitrobenzoate		C₁₁H₁₂FNO₄	详情	详情
(IV)	55905	tert-butyl 4-amino-2-fluorobenzoate		C₁₁H₁₄FNO₂	详情	详情
(V)	55906	tert-butyl 4-{[(benzyloxy)carbonyl]amino}-2-fluorobenzoate		C₁₉H₂₀FNO₄	详情	详情
(VI)	18385	(2R)oxiranylmethyl butyrate;(R)-glycidyl butyrate	60456-26-0	C₇H₁₂O₃	详情	详情
(VII)	55907	tert-butyl 2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzoate		C₁₅H₁₈FNO₅	详情	详情
(VIII)	55908	tert-butyl 4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoate		C₁₅H₁₇FN₄O₄	详情	详情
(IX)	55909	4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid		C₁₁H₉FN₄O₄	详情	详情
(X)	58661	tert-butyl 4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenylcarbamate		C₁₅H₁₈FN₅O₄	详情	详情
(XI)	58662	tert-butyl 4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenyl(methyl)carbamate		C₁₆H₂₀FN₅O₄	详情	详情
(XII)	58663	tert-butyl 4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenyl(methyl)carbamate		C₁₆H₂₂FN₃O₄	详情	详情

合成路线2

该中间体在本合成路线中的序号：(II)

Oxidation of 2-fluoro-4-nitrotoluene (I) by means of Jones reagent afforded the benzoic acid (II). After activation of (II) as the corresponding acid chloride with SOCl2, reaction with lithium tert-butoxide furnished the tert-butyl ester (III). Reduction of the nitro group of (III) by means of iron powder gave amine (IV), which was further converted into the carbamate (V) upon treatment with benzyl chloroformate. The chiral oxazolidinone (VII) was prepared by condensation of the lithium salt of carbamate (V) with (R)-glycidyl butyrate (VI) at -78 C. After activation of the primary hydroxyl of (VII) as the corresponding mesylate, displacement with NaN3 in hot DMF provided the alkyl azide (VIII). Tert-Butyl ester cleavage in (VIII) employing trifluoroacetic acid afforded the carboxylic acid (IX), which was cyclized to the thiadiazole (XI) by condensation with thiosemicarbazide (X) in the presence of POCl3. Reduction of the azido group of (XI) to the primary amine (XII) was accomplished by treatment with triphenylphosphine followed by aqueous hydrolysis. Finally, acylation of the aliphatic amino group of (XII) with ethyl dithioacetate gave rise to the title thioacetamide.

参考文献中间体

合成目标

【1】 Gordeev, M.F.; Trias, J.; Lopez, S.; Hackbarth, C.J.; Fan, P.; Gadwood, R.C.; Luehr, G.W.; Patel, D.V.; Antimicrobial activity of novel 1,3,4-thiadiazole, 1,3,4-oxadiazole, and benzimidazole phenyloxazolidinones. 41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001, Chicago) 2001, Abst F-1046.
【2】 Patel, D.V.; Gadwood, R.C.; Gordeev, M.F.; Luehr, G.W. (Pharmacia Corp.); Oxazolidinones and their use as antiinfectives. EP 1200416; US 6441005; WO 0109107 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	55902	2-Fluoro-4-nitrotoluene; 4-Nitro-2-fluorotoluene	1427-07-2	C₇H₆FNO₂	详情	详情
(II)	55903	2-Fluoro-4-nitrobenzoic acid	403-24-7	C₇H₄FNO₄	详情	详情
(III)	55904	tert-butyl 2-fluoro-4-nitrobenzoate		C₁₁H₁₂FNO₄	详情	详情
(IV)	55905	tert-butyl 4-amino-2-fluorobenzoate		C₁₁H₁₄FNO₂	详情	详情
(V)	55906	tert-butyl 4-{[(benzyloxy)carbonyl]amino}-2-fluorobenzoate		C₁₉H₂₀FNO₄	详情	详情
(VI)	18385	(2R)oxiranylmethyl butyrate;(R)-glycidyl butyrate	60456-26-0	C₇H₁₂O₃	详情	详情
(VII)	55907	tert-butyl 2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzoate		C₁₅H₁₈FNO₅	详情	详情
(VIII)	55908	tert-butyl 4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoate		C₁₅H₁₇FN₄O₄	详情	详情
(IX)	55909	4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid		C₁₁H₉FN₄O₄	详情	详情
(X)	12954	1-Hydrazinecarbothioamide; Thiosemicarbazide	79-19-6	CH₅N₃S	详情	详情
(XI)	55910	(5R)-3-[4-(5-amino-1,3,4-thiadiazol-2-yl)-3-fluorophenyl]-5-(azidomethyl)-1,3-oxazolidin-2-one		C₁₂H₁₀FN₇O₂S	详情	详情
(XII)	55911	(5S)-5-(aminomethyl)-3-[4-(5-amino-1,3,4-thiadiazol-2-yl)-3-fluorophenyl]-1,3-oxazolidin-2-one		C₁₂H₁₂FN₅O₂S	详情	详情

合成路线3

该中间体在本合成路线中的序号：(II)

Oxidation of 2-fluoro-4-nitrotoluene (I) by means of periodic acid and CrO3 affords 2-fluoro-4-nitrobenzoic acid (II), which by chlorination with SOCl2 in DMF at –5 °C, followed by condensation with methylamine, yields 2-fluoro-N-methyl-4-nitrobenzamide (III). Reduction of the nitro group in compound (III) with Fe in refluxing AcOH/EtOAc gives amine (IV), which is then condensed with pure acetone cyanohydrin (V) in the presence of anhydrous MgSO4 at 80 °C to provide 4-(1-cyano-1-methylethylamino)-2-fluoro-Nmethylbenzamide (VI). Finally, compound (VI) is condensed with 4-isothiocyanato-2-(trifluoromethyl)benzonitrile (VII) (prepared by reaction of 4-amino-2-(trifluoromethyl)benzonitrile (VIII) with thiophosgene in H2O) in DMF heated to 100 °C under microwave irradiation, and then cyclized by means of HCl in refluxing MeOH .

参考文献中间体

合成目标

【1】 Sawyers, C.L., Jung, M.E., Chen, C.D., Ouk, S., Welsbie, D., Tran, C., Wongvipat, J., Yoo, D. (University of California, Oakland). Diarylhydantoin compounds. EP 1893196, JP 2008540523, US 2007004753, US 7709517, WO 2006124118.
【2】 Jung, M., Yoo, D., Sawyers, C.L., Tran, C. (University of California, Oakland). Diarylthiohydantoin compounds. EP 2013187, JP 2009531449, US 2007254933, US 2008139634, WO 2007127010.
【3】 Jung, M.E., Ouk, S., Yoo, D., Sawyers, C.L., Chen, C., Tran, C., Wongvipat, J. Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC). J Med Chem 2010 53(10): 2779-96.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	55902	2-Fluoro-4-nitrotoluene; 4-Nitro-2-fluorotoluene	1427-07-2	C₇H₆FNO₂	详情	详情
(II)	55903	2-Fluoro-4-nitrobenzoic acid	403-24-7	C₇H₄FNO₄	详情	详情
(III)	68796	2-fluoro-N-methyl-4-nitrobenzamide		C₈H₇FN₂O₃	详情	详情
(IV)	67496	4-amino-2-fluoro-N-methylbenzamide		C₈H₉FN₂O	详情	详情
(V)	18029	Acetone cyanohydrin; 2-Hydroxy-2-methylpropanenitrile; 2-Hydroxy-2-methylpropionitrile; 2-Hydroxyisobutyronitrile; 2-Methyllactonitrile; alpha-Hydroxyisobutyronitrile	75-86-5	C₄H₇NO	详情	详情
(VI)	68797	4-(1-cyano-1-methylethylamino)-2-fluoro-N-methylbenzamide		C₁₂H₁₄FN₃O	详情	详情
(VII)	68798	4-isothiocyanato-2-(trifluoromethyl)benzonitrile；4-Cyano-3-trifluoromethylphenylisothiocyanate	143782-23-4	C₉H₃F₃N₂S	详情	详情
(VIII)	18743	4-amino-2-(trifluoromethyl)benzonitrile；5-Amino-2-cyanobenzotrifluoride	654-70-6	C₈H₅F₃N₂	详情	详情

Extended Information