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【结 构 式】

【分子编号】48664

【品名】[2-(benzyl-2-methylanilino)phenyl](4-morpholinyl)methanone

【CA登记号】

【 分 子 式 】C25H26N2O2

【 分 子 量 】386.49372

【元素组成】C 77.69% H 6.78% N 7.25% O 8.28%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Syntheses of intermediate (V), 5-benzyl-10,11-dihydro-5H-dibenz[b,f]azepin-10-one: Cyclization of either 2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-dimethylbenzamide (I), 2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-diethylbenzamide (II), 2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-diisopropylbenzamide (III) or the morpholine derivative (IV) by means of LDA and TMEDA in THF.

1 Lohse, O.; Kaufmann, D.; France, J.; Beutler, U.; Funfschilling, P.; Zaugg, W.; Furet, P.; New synthesis of oxcarbazepine via remote metalation of protected N-o-tolyl-anthranilamide derivatives. Tetrahedron Lett 2001, 42, 3, 385.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 48661 2-(benzyl-2-methylanilino)-N,N-dimethylbenzamide C23H24N2O 详情 详情
(II) 48662 2-(benzyl-2-methylanilino)-N,N-diethylbenzamide C25H28N2O 详情 详情
(III) 48663 2-(benzyl-2-methylanilino)-N,N-diisopropylbenzamide C27H32N2O 详情 详情
(IV) 48664 [2-(benzyl-2-methylanilino)phenyl](4-morpholinyl)methanone C25H26N2O2 详情 详情
(V) 48665 5-benzyl-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one C21H17NO 详情 详情
Extended Information