2-(benzyl-2-methylanilino)-N,N-diisopropylbenzamide -Drug Synthesis Database

【结构式】

【分子编号】48663

【品名】2-(benzyl-2-methylanilino)-N,N-diisopropylbenzamide

【CA登记号】

【分子式】C₂₇H₃₂N₂O

【分子量】400.56396

【元素组成】C 80.96% H 8.05% N 6.99% O 3.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Syntheses of intermediate (V), 5-benzyl-10,11-dihydro-5H-dibenz[b,f]azepin-10-one: Cyclization of either 2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-dimethylbenzamide (I), 2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-diethylbenzamide (II), 2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-diisopropylbenzamide (III) or the morpholine derivative (IV) by means of LDA and TMEDA in THF.

参考文献中间体

合成目标

【1】 Lohse, O.; Kaufmann, D.; France, J.; Beutler, U.; Funfschilling, P.; Zaugg, W.; Furet, P.; New synthesis of oxcarbazepine via remote metalation of protected N-o-tolyl-anthranilamide derivatives. Tetrahedron Lett 2001, 42, 3, 385.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	48661	2-(benzyl-2-methylanilino)-N,N-dimethylbenzamide	C₂₃H₂₄N₂O	详情	详情
(II)	48662	2-(benzyl-2-methylanilino)-N,N-diethylbenzamide	C₂₅H₂₈N₂O	详情	详情
(III)	48663	2-(benzyl-2-methylanilino)-N,N-diisopropylbenzamide	C₂₇H₃₂N₂O	详情	详情
(IV)	48664	[2-(benzyl-2-methylanilino)phenyl](4-morpholinyl)methanone	C₂₅H₂₆N₂O₂	详情	详情
(V)	48665	5-benzyl-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one	C₂₁H₁₇NO	详情	详情

Extended Information