7-(3-chloropropoxy)-4-(2,4-dichloroanilino)-6-methoxy-3-quinolinecarbonitrile -Drug Synthesis Database

【结构式】

【分子编号】48520

【品名】7-(3-chloropropoxy)-4-(2,4-dichloroanilino)-6-methoxy-3-quinolinecarbonitrile

【CA登记号】

【分子式】C₂₀H₁₆Cl₃N₃O₂

【分子量】436.72416

【元素组成】C 55% H 3.69% Cl 24.35% N 9.62% O 7.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

In an alternative synthesis, the chloropropoxy derivative (III) was similarly condensed with 2,4-dichloroaniline (II) to give (IV), which was then treated with morpholine (V), yielding the title compound.

参考文献中间体

合成目标

【1】 Boschelli, D.H.; Wang, Y.D.; Ye, F.; et al.; Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles. J Med Chem 2001, 44, 5, 822.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	48518	2,4-dichlorobenzeneamine; 2,4-Dichloroaniline	554-00-7	C₆H₅Cl₂N	详情	详情
(III)	48519	4-chloro-7-(3-chloropropoxy)-6-methoxy-3-quinolinecarbonitrile		C₁₄H₁₂Cl₂N₂O₂	详情	详情
(IV)	48520	7-(3-chloropropoxy)-4-(2,4-dichloroanilino)-6-methoxy-3-quinolinecarbonitrile		C₂₀H₁₆Cl₃N₃O₂	详情	详情
(V)	10388	Morpholine	110-91-8	C₄H₉NO	详情	详情

Extended Information