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【结 构 式】 
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【药物名称】 【化学名称】4-(2,4-Dichlorophenylamino)-6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-3-carbonitrile 【CA登记号】331662-69-2 【 分 子 式 】C24H24Cl2N4O3 【 分 子 量 】487.38988 |
【开发单位】Wyeth Pharmaceuticals (Originator) 【药理作用】Bone Diseases, Treatment of, METABOLIC DRUGS, ONCOLYTIC DRUGS, Treatment of Osteoporosis, Inhibitors of Signal Transduction Pathways, Src Kinase Inhibitors |
合成路线1
Chloroquinoline derivative (I) was condensed with 2,4-dichloroaniline (II) in boiling ethoxyethanol in the presence of pyridine hydrochloride to furnish the title compound.
| 【1】 Boschelli, D.H.; Wang, Y.D.; Ye, F.; et al.; Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles. J Med Chem 2001, 44, 5, 822. |
合成路线2
In an alternative synthesis, the chloropropoxy derivative (III) was similarly condensed with 2,4-dichloroaniline (II) to give (IV), which was then treated with morpholine (V), yielding the title compound.
| 【1】 Boschelli, D.H.; Wang, Y.D.; Ye, F.; et al.; Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles. J Med Chem 2001, 44, 5, 822. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 48518 | 2,4-dichlorobenzeneamine; 2,4-Dichloroaniline | 554-00-7 | C6H5Cl2N | 详情 | 详情 |
| (III) | 48519 | 4-chloro-7-(3-chloropropoxy)-6-methoxy-3-quinolinecarbonitrile | C14H12Cl2N2O2 | 详情 | 详情 | |
| (IV) | 48520 | 7-(3-chloropropoxy)-4-(2,4-dichloroanilino)-6-methoxy-3-quinolinecarbonitrile | C20H16Cl3N3O2 | 详情 | 详情 | |
| (V) | 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 |
Extended Information