[1,6]naphthyridin-2-amine; [1,6]naphthyridin-2-ylamine -Drug Synthesis Database

【结构式】

【分子编号】48495

【品名】[1,6]naphthyridin-2-amine; [1,6]naphthyridin-2-ylamine

【CA登记号】

【分子式】C₈H₇N₃

【分子量】145.1638

【元素组成】C 66.19% H 4.86% N 28.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Treatment of 2-isopropoxyphenylamine (I) with triphosgene (II) and DIEA in dichloromethane affords isocyanate (III), which is then converted into the desired urea derivative by treatment with amine (IV) in refluxing acetonitrile.

参考文献中间体

合成目标

【2】 Bedard, J.; Rando, R.; Falardeau, G.; Lavallee, J.-F. (BioChem Pharma Inc.); Antiviral cpds.. WO 9929318 .
【1】 Jin, H.; Chan, L.C.-K.; Wang, W.; Stefanac, T.; Mansour, T.S.; Nguyen-Ba, P.; Lavallee, J.-F.; Falardeau, G. (Shire BioChem Inc.); Naphthyridine derivs. and their analogues inhibiting cytomegalovirus. EP 0984967; JP 2001515464; US 5945431; WO 9734894 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	48493	2-isopropoxyaniline; 2-isopropoxyphenylamine		C₉H₁₃NO	详情	详情
(II)	44149	bis(trichloromethyl) carbonate;Triphosgene	32315-10-9	C₃Cl₆O₃	详情	详情
(III)	48494	2-isopropoxyphenyl isocyanate; 1-isocyanato-2-isopropoxybenzene		C₁₀H₁₁NO₂	详情	详情
(IV)	48495	[1,6]naphthyridin-2-amine; [1,6]naphthyridin-2-ylamine		C₈H₇N₃	详情	详情

Extended Information