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【结 构 式】 
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【药物名称】 【化学名称】N-(2-Isopropoxyphenyl)-N'-(1,6-naphthyridin-2-yl)urea 【CA登记号】197507-01-0 【 分 子 式 】C18H18N4O2 【 分 子 量 】322.36976 |
【开发单位】Shire BioChem (Originator) 【药理作用】Anti-Cytomegalovirus Drugs, ANTIINFECTIVE THERAPY, Antiviral Drugs |
合成路线1
Treatment of 2-isopropoxyphenylamine (I) with triphosgene (II) and DIEA in dichloromethane affords isocyanate (III), which is then converted into the desired urea derivative by treatment with amine (IV) in refluxing acetonitrile.
| 【2】 Bedard, J.; Rando, R.; Falardeau, G.; Lavallee, J.-F. (BioChem Pharma Inc.); Antiviral cpds.. WO 9929318 . |
| 【1】 Jin, H.; Chan, L.C.-K.; Wang, W.; Stefanac, T.; Mansour, T.S.; Nguyen-Ba, P.; Lavallee, J.-F.; Falardeau, G. (Shire BioChem Inc.); Naphthyridine derivs. and their analogues inhibiting cytomegalovirus. EP 0984967; JP 2001515464; US 5945431; WO 9734894 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 48493 | 2-isopropoxyaniline; 2-isopropoxyphenylamine | C9H13NO | 详情 | 详情 | |
| (II) | 44149 | bis(trichloromethyl) carbonate;Triphosgene | 32315-10-9 | C3Cl6O3 | 详情 | 详情 |
| (III) | 48494 | 2-isopropoxyphenyl isocyanate; 1-isocyanato-2-isopropoxybenzene | C10H11NO2 | 详情 | 详情 | |
| (IV) | 48495 | [1,6]naphthyridin-2-amine; [1,6]naphthyridin-2-ylamine | C8H7N3 | 详情 | 详情 |
Extended Information