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【结 构 式】 
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【分子编号】48262 【品名】5-ethyl 3-methyl 4-(2-chlorophenyl)-2-methyl-6-[[2-(tritylamino)ethoxy]methyl]-1,4-dihydro-3,5-pyridinedicarboxylate 【CA登记号】 |
【 分 子 式 】C39H39ClN2O5 【 分 子 量 】651.20184 【元素组成】C 71.93% H 6.04% Cl 5.44% N 4.3% O 12.28% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(VIII)The protection of ethanolamine (I) with trityl chloride (II) in isopropanol gives N-tritylethanolamine (III), which is condensed with ethyl 4-chloroacetoacetate (IV) by means of NaH in THF to yield ethyl 4-[2-(tritylamino)ethoxy]acetoacetate (V). The cyclization of (V) with 2-chlorobenzaldehyde (VI) and methyl 3-aminocrotonate (VII) in refluxing methanol affords the protected dihydropyridine (VIII), which, without isolation, is finally detritylated by a treatment with aqueous benzenesulfonic acid.
| 【1】 Furlan, B.; Copar, A.; Jeriha, A. (LEK Pharmaceutical and Chemical Co.); 3-Ethyl 5-methyl (+)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chloro-phenyl)-1,4-dihydro-6-methyl-6-methyl-3, 5-pyridinedicarboxylate. EP 0599220; US 5389654 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10259 | Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol | 141-43-5 | C2H7NO | 详情 | 详情 |
| (II) | 48259 | 1-(2-chloro-1,1-diphenylethyl)benzene | C20H17Cl | 详情 | 详情 | |
| (III) | 48260 | 2-(tritylamino)-1-ethanol | C21H21NO | 详情 | 详情 | |
| (IV) | 23541 | ethyl 4-chloro-3-oxobutanoate；Ethyl 4-chloro-3-oxobutanoate；Ethyl 4-chloroacetoacetate | 638-07-3 | C6H9ClO3 | 详情 | 详情 |
| (V) | 48261 | ethyl 3-oxo-4-[2-(tritylamino)ethoxy]butanoate | C27H29NO4 | 详情 | 详情 | |
| (VI) | 24114 | 2-chlorobenzaldehyde | 89-98-5 | C7H5ClO | 详情 | 详情 |
| (VII) | 11372 | Methyl (E)-3-amino-2-butenoate; Methyl 3-aminocrotonate | C5H9NO2 | 详情 | 详情 | |
| (VIII) | 48262 | 5-ethyl 3-methyl 4-(2-chlorophenyl)-2-methyl-6-[[2-(tritylamino)ethoxy]methyl]-1,4-dihydro-3,5-pyridinedicarboxylate | C39H39ClN2O5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(IV)
| 【1】 潘仙华，毛海舫.氨氯地平苯磺酸盐的制备方法：CN,Patent 1,927,837,2007. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 48261 | ethyl 3-oxo-4-[2-(tritylamino)ethoxy]butanoate | C27H29NO4 | 详情 | 详情 | |
| (II) | 69572 | (E)-ethyl 3-amino-4-(2-(tritylamino)ethoxy)but-2-enoate | C27H30N2O3 | 详情 | 详情 | |
| (III) | 44034 | methyl (Z)-2-acetyl-3-(2-chlorophenyl)-2-propenoate | C12H11ClO3 | 详情 | 详情 | |
| (IV) | 48262 | 5-ethyl 3-methyl 4-(2-chlorophenyl)-2-methyl-6-[[2-(tritylamino)ethoxy]methyl]-1,4-dihydro-3,5-pyridinedicarboxylate | C39H39ClN2O5 | 详情 | 详情 | |
| (V) | 69570 | Benzenesulfonic acid;Phenylsulfonic acid;Benzenemonosulfonic acid;Benzensulfonic acid;Benzenesulphonic acid; | 98-11-3 | C6H6O3S | 详情 | 详情 |
Extended Information