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【结 构 式】

【分子编号】48173

【品名】methyl 3-[(2-chloro-4-formylphenyl)sulfanyl]propanoate

【CA登记号】

【 分 子 式 】C11H11ClO3S

【 分 子 量 】258.72524

【元素组成】C 51.07% H 4.29% Cl 13.7% O 18.55% S 12.39%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(II)

Reaction of 3,4-dichlorobenzalzehyde (I) with methyl 3-mercaptopropionate in the presence of K2CO3 in hot DMF afforded the thioether (II). Subsequent condensation of (II) with malonic acid under Knoevenagel conditions produced the substituted cinnamic acid (III), which was further converted to the corresponding acid chloride (IV) upon treatment with oxalyl chloride and a catalytic amount of DMF. Coupling of acid chloride (IV) with N-acetylpiperazine (V) furnished amide (VI). Treatment of (VI) with potassium tert-butoxide caused the elimination of methyl acrylate, producing the potassium thiolate (VII). Thiolate (VII) was then condensed with 1-methyl-7-bromoindole (VIII) to give the title compound.

1 Lynch, J.K.; Link, J.; Zhu, G.-D.; Boyd, S.A.; Winn, M.; Pei, Z.; Gunawardana, I.W.; Liu, G.; Xin, Z.; Jae, H.-S.; Freeman, J.C.; Von Geldern, T.; Staeger, M.A. (Abbott Laboratories Inc.); Cell adhesion-inhibiting antiinflammatory and immune-suppressive cpds.. US 6110922; WO 0039081 .
2 Jae, H.-S.; Pei, Z.; Staeger, M.A.; Gunawardana, I.W.; Winn, M.; Freeman, J.C.; Liu, G.; Link, J.; Boyd, S.A.; Zhu, G.-D.; Von Geldern, T.W.; Xin, Z.; Lynch, J.K.; Wang, S. (Abbott Laboratories Inc.); Cell adhesion-inhibiting antiinflammatory and immune-suppressive cpds.. WO 0059880 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 18122 3,4-Dichlorobenzaldehyde 6287-38-3 C7H4Cl2O 详情 详情
(II) 48173 methyl 3-[(2-chloro-4-formylphenyl)sulfanyl]propanoate C11H11ClO3S 详情 详情
(III) 48174 (E)-3-[3-chloro-4-[(3-methoxy-3-oxopropyl)sulfanyl]phenyl]-2-propenoic acid C13H13ClO4S 详情 详情
(IV) 48175 methyl 3-([2-chloro-4-[(E)-3-chloro-3-oxo-1-propenyl]phenyl]sulfanyl)propanoate C13H12Cl2O3S 详情 详情
(V) 20674 N-Acetyl piperazine; 1-(1-piperazinyl)-1-ethanone 13889-98-0 C6H12N2O 详情 详情
(VI) 48176 methyl 3-([4-[(E)-3-(4-acetyl-1-piperazinyl)-3-oxo-1-propenyl]-2-chlorophenyl]sulfanyl)propanoate C19H23ClN2O4S 详情 详情
(VII) 48177 potassium 4-[(E)-3-(4-acetyl-1-piperazinyl)-3-oxo-1-propenyl]-2-chlorobenzenethiolate C15H16ClKN2O2S 详情 详情
(VIII) 29521 5-bromo-1-methyl-1H-indole C9H8BrN 详情 详情

合成路线2

该中间体在本合成路线中的序号:(III)

Aromatic nucleophilic substitution of 3-chloro-4-fluorobenzaldehyde (I) with methyl 3-mercaptopropionate (II) yielded the mercapto aldehyde (III). This was subjected to Knoevenagel condensation with malonic acid to furnish the cinnamic acid derivative (IV), which was further converted to the corresponding acid chloride (V) by using oxalyl chloride. Condensation of acid chloride (V) with N-acetylpiperazine (VI) yielded the diacyl piperazine (VII). The protected benzenethiol of (VII) was released by treatment of the beta-mercaptopropionate (VII) with potassium tert-butoxide to give the potassium thiolate (VIII). Finally, Ullmann coupling of (VIII) with 6-iodobenzodioxan (IX) furnished the title compound.

1 Liu, G.; Okasinski, O.F.; DeVries, P.; Mendoza, R.; Leitza, S.; Olejniczak, E.T.; von Geldern, T.W.; Huth, J.R.; Fesik, S.W.; Reilly, E.B.; Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. J Med Chem 2001, 44, 8, 1202.
2 Jae, H.-S.; Pei, Z.; Staeger, M.A.; Gunawardana, I.W.; Winn, M.; Freeman, J.C.; Liu, G.; Link, J.; Boyd, S.A.; Zhu, G.-D.; Von Geldern, T.W.; Xin, Z.; Lynch, J.K.; Wang, S. (Abbott Laboratories Inc.); Cell adhesion-inhibiting antiinflammatory and immune-suppressive cpds.. WO 0059880 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 49749 3-Chloro-4-fluorobenzaldehyde; 4-Fluoro-3-chlorobenzaldehyde 34328-61-5 C7H4ClFO 详情 详情
(II) 11418 methyl 3-sulfanylpropanoate; Methyl 3-mercaptopropionate 2935-90-2 C4H8O2S 详情 详情
(III) 48173 methyl 3-[(2-chloro-4-formylphenyl)sulfanyl]propanoate C11H11ClO3S 详情 详情
(IV) 48174 (E)-3-[3-chloro-4-[(3-methoxy-3-oxopropyl)sulfanyl]phenyl]-2-propenoic acid C13H13ClO4S 详情 详情
(V) 48175 methyl 3-([2-chloro-4-[(E)-3-chloro-3-oxo-1-propenyl]phenyl]sulfanyl)propanoate C13H12Cl2O3S 详情 详情
(VI) 20674 N-Acetyl piperazine; 1-(1-piperazinyl)-1-ethanone 13889-98-0 C6H12N2O 详情 详情
(VII) 48176 methyl 3-([4-[(E)-3-(4-acetyl-1-piperazinyl)-3-oxo-1-propenyl]-2-chlorophenyl]sulfanyl)propanoate C19H23ClN2O4S 详情 详情
(VIII) 48177 potassium 4-[(E)-3-(4-acetyl-1-piperazinyl)-3-oxo-1-propenyl]-2-chlorobenzenethiolate C15H16ClKN2O2S 详情 详情
(IX) 49750 3,4-Ethylenedioxyiodobenzene 57744-67-9 C8H7IO2 详情 详情
Extended Information