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【结 构 式】

【分子编号】48113

【品名】4-hydrazinopyrrolo[1,2-a]quinoxaline

【CA登记号】

【 分 子 式 】C11H10N4

【 分 子 量 】198.22736

【元素组成】C 66.65% H 5.08% N 28.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

Clauson-Kaas reaction between 2-fluoroaniline (I) and 2,5-dimethoxytetrahydrofuran (II) in refluxing HOAc affords pyrrolic compound (III), which is then converted into cyanopyrrole derivative (IV) through a one-pot sequence involving formylation with oxalyl chloride, oximation with NH2OH.HCl and dehydration with Ac2O. Cyclization of nitrile (IV) by treatment with KOH in ethylene glycol or in tert-butyl alcohol yields quinoxalinone derivative (V), which is then transformed into the hydrazine derivative (VI) by refluxing with POCl3 and catalytic N,N-dimethylaniline followed by treatment with hydrazine in MeOH. Finally, the desired product is obtained by reaction of (VI) with pyrazinecarboxylic acid (VII) in the presence of PPh3 and 2,2'-dipyridyl disulfide (Aldrithiol-2) in CH2Cl2.

2 Campiani, G.; et al.; Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure. J Med Chem 1997, 40, 22, 3670.
1 Campiani, G.; Fabbrini, M.; Aiello, F.; et al.; Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. J Med Chem 2001, 44, 3, 305.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22296 2-fluorophenylamine; 2-fluoroaniline 348-54-9 C6H6FN 详情 详情
(II) 12132 2,5-Dimethoxytetrahydrofuran; 5-Methoxytetrahydro-2-furanyl methyl ether 696-59-3 C6H12O3 详情 详情
(III) 48110 1-(2-fluorophenyl)-1H-pyrrole C10H8FN 详情 详情
(IV) 48111 1-(2-fluorophenyl)-1H-pyrrole-2-carbonitrile C11H7FN2 详情 详情
(V) 48112 pyrrolo[1,2-a]quinoxalin-4(5H)-one C11H8N2O 详情 详情
(VI) 48113 4-hydrazinopyrrolo[1,2-a]quinoxaline C11H10N4 详情 详情
(VII) 37256 2-pyrazinecarboxylic acid; Pyrazinoic acid 98-97-5 C5H4N2O2 详情 详情
Extended Information