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【结 构 式】

【分子编号】48052

【品名】tert-butyl (E)-4-(5-ethoxy-3-pyridinyl)-3-butenyl(methyl)carbamate

【CA登记号】

【 分 子 式 】C17H26N2O3

【 分 子 量 】306.40512

【元素组成】C 66.64% H 8.55% N 9.14% O 15.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(X)

In a related method, 4-bromo-1-butene (VII) was reacted with methylamine to produce the secondary amine (VIII). After protection of (VIII) as the tert-butyl carbamate (IX), palladium-catalyzed coupling with 3-bromo-5-ethoxypyridine (II) furnished adduct (X). The N-Boc protecting group of (X) was then cleaved under acidic conditions to afford amine precursor (VI). The title hemigalactarate salt was finally prepared by treatment of amine (VI) with D-galactaric acid in aqueous ethanol.

1 Bane, A.J.; Dull, G.M.; Bencherif, M.; Miller, C.H.; Gatto, G.J.; TC-2559: A novel orally active ligand selective at neuronal acetylcholine receptors. Eur J Pharmacol 2000, 409, 1, 45.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 48046 3-bromo-5-ethoxypyridine; 5-bromo-3-pyridinyl ethyl ether C7H8BrNO 详情 详情
(VI) 48049 N-[(E)-4-(5-ethoxy-3-pyridinyl)-3-butenyl]-N-methylamine; (E)-4-(5-ethoxy-3-pyridinyl)-N-methyl-3-buten-1-amine C12H18N2O 详情 详情
(VII) 11720 4-Bromo-1-butene 5162-44-7 C4H7Br 详情 详情
(VIII) 48050 N-(3-butenyl)-N-methylamine; N-methyl-3-buten-1-amine C5H11N 详情 详情
(IX) 48051 tert-butyl 3-butenyl(methyl)carbamate C10H19NO2 详情 详情
(X) 48052 tert-butyl (E)-4-(5-ethoxy-3-pyridinyl)-3-butenyl(methyl)carbamate C17H26N2O3 详情 详情
Extended Information