1,2,3,4-tetrahydro-8-quinolinamine; 1,2,3,4-tetrahydro-8-quinolinylamine -Drug Synthesis Database

【结构式】

【分子编号】48016

【品名】1,2,3,4-tetrahydro-8-quinolinamine; 1,2,3,4-tetrahydro-8-quinolinylamine

【CA登记号】54012-92-9

【分子式】C₉H₁₂N₂

【分子量】148.20776

【元素组成】C 72.94% H 8.16% N 18.9%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

8-Amino-1,2,3,4-tetrahydroquinoline (VII) was obtained by catalytic hydrogenation of 8-nitroquinoline (VI) over PtO2. Condensation of (VII) with sulfamide in diglyme at 160 C gave rise to the tricyclic system (VIII), which was further alkylated with 1-bromo-2-chloroethane in the presence of NaH to yield chloride (IX). Finally, condensation between tetrahydropyridine (V) and chloride (IX) afforded the title compound.

参考文献中间体

合成目标

【1】 Fairhurst, J. (Eli Lilly and Company); Substd. 4-(6-fluoro-(1H)-indol-3-yl)-1,2,3,6-tetrahydropyridine for the treatment of CNS-disorders. EP 0854146; WO 9831686 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(V)	48014	6-fluoro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole		C₁₃H₁₃FN₂	详情	详情
(VI)	48015	8-nitroquinoline	607-35-2	C₉H₆N₂O₂	详情	详情
(VII)	48016	1,2,3,4-tetrahydro-8-quinolinamine; 1,2,3,4-tetrahydro-8-quinolinylamine	54012-92-9	C₉H₁₂N₂	详情	详情
(VIII)	48017	5,6-dihydro-4H-2lambda(6)-[1,2,5]thiadiazolo[4,3,2-ij]quinoline-2,2(1H)-dione		C₉H₁₀N₂O₂S	详情	详情
(IX)	48018	1-(2-chloroethyl)-5,6-dihydro-4H-2lambda(6)-[1,2,5]thiadiazolo[4,3,2-ij]quinoline-2,2(1H)-dione		C₁₁H₁₃ClN₂O₂S	详情	详情

Extended Information