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【结 构 式】 
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【分子编号】48015 【品名】8-nitroquinoline 【CA登记号】607-35-2 |
【 分 子 式 】C9H6N2O2 【 分 子 量 】174.15892 【元素组成】C 62.07% H 3.47% N 16.09% O 18.37% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)8-Amino-1,2,3,4-tetrahydroquinoline (VII) was obtained by catalytic hydrogenation of 8-nitroquinoline (VI) over PtO2. Condensation of (VII) with sulfamide in diglyme at 160 C gave rise to the tricyclic system (VIII), which was further alkylated with 1-bromo-2-chloroethane in the presence of NaH to yield chloride (IX). Finally, condensation between tetrahydropyridine (V) and chloride (IX) afforded the title compound.
| 【1】 Fairhurst, J. (Eli Lilly and Company); Substd. 4-(6-fluoro-(1H)-indol-3-yl)-1,2,3,6-tetrahydropyridine for the treatment of CNS-disorders. EP 0854146; WO 9831686 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 48014 | 6-fluoro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole | C13H13FN2 | 详情 | 详情 | |
| (VI) | 48015 | 8-nitroquinoline | 607-35-2 | C9H6N2O2 | 详情 | 详情 |
| (VII) | 48016 | 1,2,3,4-tetrahydro-8-quinolinamine; 1,2,3,4-tetrahydro-8-quinolinylamine | 54012-92-9 | C9H12N2 | 详情 | 详情 |
| (VIII) | 48017 | 5,6-dihydro-4H-2lambda(6)-[1,2,5]thiadiazolo[4,3,2-ij]quinoline-2,2(1H)-dione | C9H10N2O2S | 详情 | 详情 | |
| (IX) | 48018 | 1-(2-chloroethyl)-5,6-dihydro-4H-2lambda(6)-[1,2,5]thiadiazolo[4,3,2-ij]quinoline-2,2(1H)-dione | C11H13ClN2O2S | 详情 | 详情 |
Extended Information