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【结 构 式】 
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【分子编号】47993 【品名】2-(3,4-dichlorophenyl)-N-ethyl-N-[2-(1-pyrrolidinyl)ethyl]acetamide 【CA登记号】 |
【 分 子 式 】C16H22Cl2N2O 【 分 子 量 】329.26896 【元素组成】C 58.36% H 6.73% Cl 21.53% N 8.51% O 4.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Diamine (II) was prepared by reaction of N-(2-chloroethyl)pyrrolidine hydrochloride (I) with ethylamine. Coupling of (II) with 3,4-dichlorophenylacetic acid (III) in the presence of DCC afforded amide (IV). The amide function of (IV) was finally reduced by means of aluminum hydride in THF to furnish the title diamine.
| 【1】 de Costa, B.R.; et al.; Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: Structural requirements and binding affinity at the sigma receptor. J Med Chem 1992, 35, 1, 38. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 33922 | 1-(2-Chloroethyl)pyrrolidine; N-(2-Chloroethyl)pyrrolidine | C6H12ClN | 详情 | 详情 | |
| (II) | 47992 | N-ethyl-2-(1-pyrrolidinyl)-1-ethanamine; N-ethyl-N-[2-(1-pyrrolidinyl)ethyl]amine | C8H18N2 | 详情 | 详情 | |
| (III) | 30414 | 2-(3,4-dichlorophenyl)acetic acid；2-(3,4-Dichlorophenyl)acetic acid | 5807-30-7 | C8H6Cl2O2 | 详情 | 详情 |
| (IV) | 47993 | 2-(3,4-dichlorophenyl)-N-ethyl-N-[2-(1-pyrrolidinyl)ethyl]acetamide | C16H22Cl2N2O | 详情 | 详情 |
Extended Information