N-ethyl-2-(1-pyrrolidinyl)-1-ethanamine; N-ethyl-N-[2-(1-pyrrolidinyl)ethyl]amine -Drug Synthesis Database

【结构式】

【分子编号】47992

【品名】N-ethyl-2-(1-pyrrolidinyl)-1-ethanamine; N-ethyl-N-[2-(1-pyrrolidinyl)ethyl]amine

【CA登记号】

【分子式】C₈H₁₈N₂

【分子量】142.2444

【元素组成】C 67.55% H 12.75% N 19.69%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Diamine (II) was prepared by reaction of N-(2-chloroethyl)pyrrolidine hydrochloride (I) with ethylamine. Coupling of (II) with 3,4-dichlorophenylacetic acid (III) in the presence of DCC afforded amide (IV). The amide function of (IV) was finally reduced by means of aluminum hydride in THF to furnish the title diamine.

参考文献中间体

合成目标

【1】 de Costa, B.R.; et al.; Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: Structural requirements and binding affinity at the sigma receptor. J Med Chem 1992, 35, 1, 38.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33922	1-(2-Chloroethyl)pyrrolidine; N-(2-Chloroethyl)pyrrolidine		C₆H₁₂ClN	详情	详情
(II)	47992	N-ethyl-2-(1-pyrrolidinyl)-1-ethanamine; N-ethyl-N-[2-(1-pyrrolidinyl)ethyl]amine		C₈H₁₈N₂	详情	详情
(III)	30414	2-(3,4-dichlorophenyl)acetic acid；2-(3,4-Dichlorophenyl)acetic acid	5807-30-7	C₈H₆Cl₂O₂	详情	详情
(IV)	47993	2-(3,4-dichlorophenyl)-N-ethyl-N-[2-(1-pyrrolidinyl)ethyl]acetamide		C₁₆H₂₂Cl₂N₂O	详情	详情

Extended Information