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【结 构 式】

【分子编号】47948

【品名】methyl 2-bromo-2-(3,4-dichlorophenyl)acetate

【CA登记号】

【 分 子 式 】C9H7BrCl2O2

【 分 子 量 】297.96278

【元素组成】C 36.28% H 2.37% Br 26.82% Cl 23.8% O 10.74%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

Reaction of 2-chloropyrazine (I) with 3,4-dichlorophenylmagnesium bromide (II) in the presence of [1,2-bis(diphenylphosphino)ethane]nickel(II) chloride produced the 2-arylpyrazine (III), which was reduced to the corresponding piperazine (IV) by means of DIBAL in THF. In a different procedure, bromination of methyl 3,4-dichlorophenylacetate (V) using N-bromosuccinimide, followed by reaction of the resulting bromo ester (VI) with ethylenediamine (VII) afforded the piperazinone (VIII), which was further reduced to (IV) by using LiAlH4 in Et2O.

1 Anthes, J.C.; McPhail, A.T.; Blythin, D.J.; Shue, H.-J.; Chen, X.; Piwinski, J.J.; shih, N.-Y.; Discovery of Sch 62373 and analogs, of novel series of 2-phenylpiperazines exhibiting potent dual NK1/NK2 antagonist activity. 221st ACS Natl Meet (April 1 2001, San Diego) 2001, Abst MEDI 244.
2 Shue, H.-J.; Shih, N.-Y.; Blythin, D.J.; Chen, X.; Tom, W.C.; Piwinski, J.J.; McCormick, K.D. (Schering Corp.); Piperazino derivs. as neurokinin antagonists. EP 0823906; US 5719156; WO 9634864 .
3 Piwinski, J.J.; McCormick, K.D.; Shue, H.-J.; Chen, X.; Shih, N.-Y.; Blythin, D.J. (Schering Corp.); Piperazino derivs. as neurokinin antagonists. EP 0850236; JP 2000344766; US 5795894; US 5892039; WO 9708166 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24075 2-chloropyrazine 14508-49-7 C4H3ClN2 详情 详情
(II) 10069 Bromo(3,4-dichlorophenyl)magnesium 79175-35-2 C6H3BrCl2Mg 详情 详情
(III) 47945 2-(3,4-dichlorophenyl)pyrazine C10H6Cl2N2 详情 详情
(IV) 47946 2-(3,4-dichlorophenyl)piperazine C10H12Cl2N2 详情 详情
(V) 47947 methyl 2-(3,4-dichlorophenyl)acetate C9H8Cl2O2 详情 详情
(VI) 47948 methyl 2-bromo-2-(3,4-dichlorophenyl)acetate C9H7BrCl2O2 详情 详情
(VII) 14754 ethylenediamine;1,2-Diaminoethane;ethane-1,2-diamine;1,2-Ethanediamine 107-15-3 C2H8N2 详情 详情
(VIII) 47949 3-(3,4-dichlorophenyl)-2-piperazinone C10H10Cl2N2O 详情 详情
Extended Information