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【结 构 式】 
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【分子编号】47924 【品名】 【CA登记号】 |
【 分 子 式 】C49H68N4NiO 【 分 子 量 】787.79868 【元素组成】C 74.71% H 8.7% N 7.11% Ni 7.45% O 2.03% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The reaction of octaethylporphyrin (I) with 3-(dimethylamino)acrolein (II) by means of POCl3 gives the 10-(2-formylvinyl)octaethylporphyrin (III), which is treated with decylmagnesium bromide (IV) in THF to yield the corresponding alcohol (V). The cyclization of (V) in concentrated H2SO4 affords the decylbenzochlorin (VI), which is finally treated with zinc acetate in methanol/dichloromethane to provide the target zinc complex.
| 【1】 Li, G.; et al.; A simple and efficient approach for the synthesis of fluorinated and nonfluorinated octaethylporphyrin-based benzochlorins with variable lipophilicity. Their in vivo tumor uptake, and the preliminary in vitro photosensitizing. J Org Chem 2001, 66, 4, 1316. |
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