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【结 构 式】 
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【药物名称】 【化学名称】[2(1)-Decyl-3,3,7,8,12,13,17,18-octaethyl-3H-benzo[at]porphyrinato(2-)]zinc 【CA登记号】332108-89-1 【 分 子 式 】C49H66N4Zn 【 分 子 量 】776.46917 |
【开发单位】Roswell Park Cancer Institute (Originator) 【药理作用】ONCOLYTIC DRUGS, Photodynamic Therapy, Photosensitizers, Radiation Therapy |
合成路线1
The reaction of octaethylporphyrin (I) with 3-(dimethylamino)acrolein (II) by means of POCl3 gives the 10-(2-formylvinyl)octaethylporphyrin (III), which is treated with decylmagnesium bromide (IV) in THF to yield the corresponding alcohol (V). The cyclization of (V) in concentrated H2SO4 affords the decylbenzochlorin (VI), which is finally treated with zinc acetate in methanol/dichloromethane to provide the target zinc complex.
| 【1】 Li, G.; et al.; A simple and efficient approach for the synthesis of fluorinated and nonfluorinated octaethylporphyrin-based benzochlorins with variable lipophilicity. Their in vivo tumor uptake, and the preliminary in vitro photosensitizing. J Org Chem 2001, 66, 4, 1316. |