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【结 构 式】 
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【分子编号】47307 【品名】4-[1-benzofuran-2-yl(chloro)methyl]benzonitrile 【CA登记号】 |
【 分 子 式 】C16H10ClNO 【 分 子 量 】267.71424 【元素组成】C 71.78% H 3.76% Cl 13.24% N 5.23% O 5.98% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Methanol derivative (I) is converted into the corresponding methyl chloride compound (II) by reaction with thionyl chloride in dichloromethane/cyclohexane. The desired product is then obtained by displacement of the chlorine by attack with 1H-1,2,4-triazole (III) in dioxane.
| 【1】 Pestellini, V.; Ghelardoni, M.; Giannotti, D.; Giolitti, A.; Barzanti, A.; Ciappi, R.; Ortolani, C. (Menarini Industrie Farma Riunite Srl); New (benzofuran-2-yl)imidazoles having pharmaceutically activity, their salts and relevant production processes. EP 0257171; JP 1988072687; US 4800208 . |
| 【2】 Lombardi, P.; Di Pietro, G. (Menarini Industrie Farma Riunite Srl); Heterocyclic furan cpds., their preparation and use as aromatase inhibitors. WO 9818791 . |
Extended Information