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【结 构 式】 
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【药物名称】MEN-11066 【化学名称】(±)-4-[1-(Benzofuran-2-yl)-1-(1,2,4-triazol-1-yl)methyl]- benzonitrile 【CA登记号】 【 分 子 式 】C18H12N4O 【 分 子 量 】300.32254 |
【开发单位】Menarini 【药理作用】ONCOLYTIC DRUGS，HORMONAL AGENTS |
合成路线1
Methanol derivative (I) is converted into the corresponding methyl chloride compound (II) by reaction with thionyl chloride in dichloromethane/cyclohexane. The desired product is then obtained by displacement of the chlorine by attack with 1H-1,2,4-triazole (III) in dioxane.
| 【1】 Pestellini, V.; Ghelardoni, M.; Giannotti, D.; Giolitti, A.; Barzanti, A.; Ciappi, R.; Ortolani, C. (Menarini Industrie Farma Riunite Srl); New (benzofuran-2-yl)imidazoles having pharmaceutically activity, their salts and relevant production processes. EP 0257171; JP 1988072687; US 4800208 . |
| 【2】 Lombardi, P.; Di Pietro, G. (Menarini Industrie Farma Riunite Srl); Heterocyclic furan cpds., their preparation and use as aromatase inhibitors. WO 9818791 . |
Extended Information